Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
It was well documented that hypoxia-inducible factor-1α and fatty acid synthase were overexpressed in mammary gland carcinomas.
|
30950543 |
2019 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, to know the role of HIF-1α in the apoptosis of fish cells, we produced HIF-1α knockout Epithelioma papulosum cyprini (EPC) cells using a CRISPR/Cas9 vector, and a single cell clone showing a heterozygous insertion/deletion (indel) mutation (one nucleotide insertion and one nucleotide deletion in HIF-1α gene) was chosen for further experiments.
|
30220031 |
2018 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
This mechanism of HIF1α degradation might operate in some VHL-related clear-cell renal carcinomas in which the deletion of HIF1α locus does not occur.
|
25915846 |
2016 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We investigated CXCR4 and CXCR7 mRNA and protein expression in human colon carcinomas and the modulation of their expression by hypoxia and HIF-1α in colon cancer cell lines.
|
24629239 |
2014 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
HIF-1alpha protein expression was lower in effusions compared to primary carcinomas and solid metastases (P = 0.033).
|
20213325 |
2010 |
Carcinoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas.
|
19808899 |
2010 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
HIF-1alpha isoforms containing a three base pairs TAG insertion between exon 1 and exon 2 (designated HIF-1alphaTAG) and HIF-1alpha736 mRNAs were found expressed at higher levels in oestrogen receptor (OR)-negative carcinomas compared to normal/benign tissues (P = 0.009 and P = 0.004 respectively).
|
20624301 |
2010 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In addition, both human and hamster oral carcinomas displayed invasive, and angiogenic properties as revealed by dysregulated cytokeratin expression, downregulation of RECK, and increased expression of uPA, MMP-2 and-9, HIF-1alpha, and VEGF.
|
19250857 |
2009 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The present observations support that upregulation of HIF-1 alpha and its downstream targets GLUT1 and SDF-1 in colorectal adenomas and carcinomas may be due to hypoxia, in close interaction with an active phosphatidylinositol 3-kinases-AKT-mTOR pathway.
|
18351386 |
2008 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry performed on tissue array slides containing 268 surgical specimens of gastric carcinomas showed immunoreactivity for HIF-1alpha in 29% of samples.
|
17984117 |
2008 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In 22 clear cell carcinomas, VHL expression showed a significantly negative correlation with the nuclear expression of HIF-1alpha (rho = -0.529, P = .0153).
|
17555795 |
2007 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Overexpression of HIF-1alpha in gastric carcinomas may upregulate its downstream gene products leading to VEGF-mediated angiogenesis, and resulting in a poor prognosis for patients.
|
16847924 |
2006 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This study was designed to analyze the correlation of the expression and subcellular localization of PHD2 with the pathologic features of human carcinomas and HIF-1alpha expression.
|
16489060 |
2006 |
Carcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Immunohistochemically, nuclear localization of HIF-1alpha was observed in 32 of the 76 (42%) carcinomas studied, and showed a topological correlation with loss of E-cadherin expression.
|
14507651 |
2003 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
There was no relationship between HIF-1 alpha or VEGF gene expression level and IMD in all carcinomas (R=0.118 and 0.224, respectively).
|
11804750 |
2002 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Increased expression of HIF-1alpha gene (HIF1A) has been found in the majority of prostate carcinomas.
|
11454426 |
2001 |
Carcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In those clear cell renal carcinomas that showed increased expression on immunoblots, HIF-1alpha was expressed in almost all cells.
|
11431362 |
2001 |