|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Contrary to expectation, our studies revealed that Hif-1α-deleted-leukemias displayed a faster disease progression after chemotherapy.
|
30595549 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
ER-INP was efficiently expressed and bound to PHD2 in cells, significantly increased the levels of HIF-1α, and decreased hydroxylated HIF-1α in human embryonic kidney cell line (HEK293) cells and mouse mononuclear macrophage leukaemia cell line (RAW264.7) cells.
|
31413262 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases represent a prosurvival pathway that is upregulated in response to hypoxia, in a HIF-1-independent manner.
|
27196781 |
2016 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Leukemia stem cells are in a hypoxic condition, which induces the expression of HIF-1α.
|
27082496 |
2016 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that in chronic lymphocytic leukemia (CLL), HIF-1α is a novel regulator of the interaction of CLL cells with protective leukemia microenvironments and, in turn, is regulated by this interaction in a positive feedback loop that promotes leukemia survival and propagation.
|
26825709 |
2016 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus high HIF1α expression serves as a reliable marker, which identifies patients with a poor prognosis in an otherwise prognostically favorable AML group and represents an innovative therapeutic target in high-risk A/E-driven leukemia.
|
25727291 |
2015 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Modulation of mRNA expression of several hypoxia-related genes was also observed after hypoxic exposure in a cell specific manner, suggesting that HIF1A mRNA expression could play a different role in specific subtypes of leukemia.
|
24160851 |
2014 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hypoxic T24 cells expressed a higher level of HIF-1α, vascular endothelial growth factor, matrix metalloproteinases-2, B-cell lymphoma/leukemia-2 protein and HIF-1α mRNA compared with normoxic controls, in which the above-mentioned expression was downregulated by YC-1 in a dose-dependent manner.
|
22041818 |
2012 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
We suggest a dual role for HIF-1alpha in providing a survival or death signal, based on hypoxia duration, and consider the nuclear transcription factor, CREB, to be a possible target for hypoxic therapy against leukemia disease.
|
18996491 |
2009 |
|
leukemia
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid x receptor alpha-dependent activation of hepatic leukemia factor.
|
18239067 |
2008 |