HIF1A, hypoxia inducible factor 1 subunit alpha, 3091

N. diseases: 1044; N. variants: 15
Disease: Thyroid Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.340 GeneticVariation disease BEFREE Mitochondrial metabolism is inhibited by the HIF1α-MYC-PGC-1β axis in BRAF V600E thyroid cancer. 30768848 2019
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.340 AlteredExpression disease BEFREE Human thyroid cancer cell line follicular thyroid carcinoma (FTC) 133 was endowed with aggressiveness by HIF-1α or β-catenin overexpression. 27840971 2017
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.340 Biomarker disease BEFREE Combining adjuvant HIF1α inhibitor chemotherapy with surgery might be an effective therapeutic strategy for thyroid cancer that is refractory to conventional treatments. 25862859 2015
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.340 Biomarker disease CTD_human Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas. 19808899 2010
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm 		0.340 Biomarker disease BEFREE These data indicate that IGF-I stimulates VEGF synthesis in thyroid carcinomas in an Akt-dependent pathway via AP-1 and HIF-1 alpha and provide the framework for clinical use of small-molecule inhibitors, including geldanamycin analogs, to abrogate proangiogenic cascades in thyroid cancer. 14602779 2003