Endometrial Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Long noncoding RNA H19 regulates HIF-1α/AXL signaling through inhibiting miR-20b-5p in endometrial cancer.
|
31411527 |
2019 |
Endometrial Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this retrospective study was to explore the possible correlation in the EC microenvironment between master regulators of complex phenomena such as steroid responsiveness through estrogen receptor alpha (ERα) and progesterone receptor (PR), epithelial-to-mesenchymal transition (supported by SLUG transcription factor), hypoxia (with hypoxia inducible factor-1 alpha, HIF-1α), and obesity that has been recognized as a EC risk factor.
|
31220580 |
2019 |
Endometrial Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that reduced expression of PHD2 and increased expression of HIF-1α are associated with endometrial cancer aggressiveness.
|
31819628 |
2019 |
Endometrial Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PD-L1 and HIF-1α expression were detected in 48.4% and 68.4% of endometrial carcinomas, respectively.
|
30539847 |
2018 |
Endometrial Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prognostic implications of epithelial to mesenchymal transition related proteins (E-cadherin, Snail) and hypoxia inducible factor 1α in endometrioid endometrial carcinoma.
|
27180053 |
2016 |
Endometrial Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using ovarian and endometrial cancer cell lines, we observed that TM downregulates HIF-1α protein levels and HIF-transcriptional targets involved in tumor angiogenesis and glycolysis, but did not affect HIF-1α protein synthesis.
|
26469226 |
2015 |
Endometrial Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
HIF-1 (hypoxia-inducible factor 1) activation is critical for the metabolic reprogramming and progression of solid tumors, and DEC2 (differentiated embryonic chondrocyte gene 2) has been recently reported to suppress HIF-1 in human breast and endometrial cancers.
|
25884381 |
2015 |
Endometrial Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that upregulation of SHARP1 suppressed tumor angiogenesis by decreasing hypoxia-inducible factor-1α (HIF-1α), inhibited cell viability and tumor growth in EC.
|
24918449 |
2014 |
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the C1772T polymorphism of the HIF-1a may be associated with endometrial cancers.
|
25556481 |
2014 |
Endometrial Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we focused on relationships of HIF-1α with NF-κB and β-catenin signaling in endometrial carcinomas (Em Cas).
|
24042437 |
2013 |
Endometrial Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Association of growth factors, HIF-1 and NF-κB expression with proteasomes in endometrial cancer.
|
22711307 |
2012 |
Endometrial Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To test the hypothesis that restoring HIF-1alpha in cultured cells would restore the ability of E(2) to induce VEGF expression, we treated human endometrial cancer cells (ECC-1) with cobalt chloride (CoCl(2);100 microm), which prevents oxygen-induced HIF-1alpha degradation.
|
19819950 |
2009 |
Endometrial Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, HIF-1alpha, which is related to tissue hypoxia in endometrial cancer, seems to be associated with overexpression of Ob and ObR.
|
17404022 |
2007 |
Endometrial Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the C1772T polymorphism of the HIF-1 alpha may be associated with cervical and endometrial cancers.
|
17418979 |
2007 |
Endometrial Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Hypoxia caused an increase in HIF-1alpha protein expression in 4 endometrial carcinoma cell lines.
|
17342330 |
2007 |
Endometrial Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The angiogenic mediator HIF-1alpha, linked to Angs and IL-8, might work on angiogenesis with myometrial invasion of cancer cells in uterine endometrial cancers.
|
17341889 |
2006 |