HIF1A, hypoxia inducible factor 1 subunit alpha, 3091

N. diseases: 1044; N. variants: 15
Disease: Epithelial ovarian cancer ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.090 AlteredExpression disease BEFREE Epithelial ovarian cancer stem‑like cells are resistant to the cellular lysis of cytokine‑induced killer cells via HIF1A‑mediated downregulation of ICAM‑1. 31059002 2019
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.090 AlteredExpression disease BEFREE Our findings showed that ADM expression was positively correlated with the expressions of HIF-1α, VEGF or MVD in EOC. 28091613 2017
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.090 AlteredExpression disease BEFREE The present study indicated that the HIF-1α protein was expressed and increased in EOC cell line. 27044634 2016
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.090 AlteredExpression disease BEFREE In epithelial ovarian cancer (EOC) cells, ET-1/ET(A)R axis induced vascular-endothelial growth factor (VEGF) expression through HIF-1α nuclear accumulation. 26909598 2016
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.090 AlteredExpression disease BEFREE Hypoxia inducible factor 1α-mediated LOX expression correlates with migration and invasion in epithelial ovarian cancer. 23545606 2013
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.090 Biomarker disease BEFREE Dichloroacetate induced apoptosis, reduced MPO, iNOS, and HIF-1a, whereas increased SOD, in both EOC cell lines. 21701041 2011
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.090 AlteredExpression disease BEFREE Semi-quantitative analysis of the angiogenesis assay revealed a significant reduction in tube formation when supernatant from HIF-1 alpha siRNA-treated hypoxic EOC cell was used (P < 0.05). 20140681 2010
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.090 AlteredExpression disease BEFREE The present study suggested that the expression level of HIF-1alpha could be an independent prognostic factor in epithelial ovarian cancer. 18476949 2008
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.090 Biomarker disease BEFREE The objective of this study was to investigate the effects of prostaglandin E(2) (PGE(2)) on the expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible transcription factor-1 alpha (HIF-1alpha) genes in epithelial ovarian cancer (EOC) cells. 15297183 2004