ANXA7, annexin A7, 310

N. diseases: 55; N. variants: 0
Disease: Prostatic Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.030 Biomarker group BEFREE The tumor suppressor role of annexin-A7 (ANXA7) was previously demonstrated by cancer susceptibility in Anxa7(+/-)-mice and by ANXA7 loss in human cancers, especially in hormone-resistant prostate tumors. 19610065 2009
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.030 GeneticVariation group BEFREE Loss of heterozygosity (LOH) in the 10q21 region that harbors the tumor suppressor gene ANX7-GTPase gene have been found in 35% of prostate tumors. 15183540 2004
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.030 AlteredExpression group BEFREE Consistently, analysis of ANX7 protein expression in human prostate tumor microarrays reveals a significantly higher rate of loss of ANX7 expression in metastatic and local recurrences of hormone refractory prostate cancer as compared with primary tumors (P = 0.0001). 11287641 2001