Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association of ERAP1 and ERAP2 single nucleotide polymorphisms and their haplotypes with psoriasis vulgaris is dependent on the presence or absence of the HLA-C*06:02 allele and age at disease onset.
|
29183862 |
2018 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition to HLA-A*02:07 and HLA-C*06:02, stepwise conditional analysis identified an independent PsV risk of HLA-DQβ1 Asp57 (odds ratio = 2.19, P = 1.9 × 10<sup>-6</sup>).
|
29031612 |
2018 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Stepwise analysis revealed multiple HLA-C(∗)06:02-independent risk variants in both class I and class II HLA genes for PsV susceptibility (HLA-C(∗)12:03, HLA-B amino acid positions 67 and 9, HLA-A amino acid position 95, and HLA-DQα1 amino acid position 53; p < 5.0 × 10(-8)), but no apparent risk conferred by MICA.
|
25087609 |
2014 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, rs9264942C allele was predisposing to PsV 3-fold weaker than HLA-Cw(∗)06 (OR=5.04 vs. OR=15.61, respectively).
|
24759677 |
2014 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Susceptibility to psoriasis vulgaris in our study group is significantly associated with HLA-C*06 (odds ratio (OR) = 3.85), DRB1*07 (OR = 2.56) and DQB1*02 (OR = 1.09), respectively, whereas DRB*01 (OR = 0.05) is associated negatively.
|
23184486 |
2013 |
Psoriasis vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association between HLA-Cw*06 and PsA was low (P corrected = 0.0585) and restricted to PsA patients with early PsV onset (P corrected = 0.0195).
|
22821332 |
2013 |
Psoriasis vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-C is firmly established as a PsV/PsA gene, with HLA-Cw*0602 as a major risk allele.
|
22298274 |
2012 |
Psoriasis vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using a candidate gene approach, genes robustly confirmed to be associated with psoriasis vulgaris (PsV) have also been found to be associated with PsA (HLA-Cw*0602, IL23R, IL12B).
|
20084005 |
2010 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For PsA, but not psoriasis vulgaris without joint involvement, a strong association with the allele TNF*-857T (odds ratio 1.956 [95% confidence interval 1.334-2.881]; corrected P = 0.0025) was also detected in patients negative for the PSORS1 risk allele.
|
17530646 |
2007 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
With regards to HLA-Cw*0602, its allele frequency was significantly increased in patients with early-onset PV (25.3% vs. 4.8%, P < 10(-7)), but not in patients with PsA.
|
17388919 |
2007 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The HLA-C locus profile of this cohort was studied by methods based on molecular biology and was compared with that of 45 patients with psoriasis vulgaris and 177 healthy blood donors from the same ethnic origin.
|
17166285 |
2006 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PSORS1 is the major susceptibility locus for psoriasis vulgaris (PV) and lies within an approximately 200 kb segment of the major histocompatibility complex on chromosome 6p21.3.
|
15654960 |
2005 |
Psoriasis vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Association between psoriasis vulgaris and MHC-DRB, -DQB genes as a contribution to disease diagnosis.
|
15908298 |
2005 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PSORS1 on chromosome 6p21.3, which contains the MHC, is a major susceptibility locus for psoriasis vulgaris.
|
15953084 |
2005 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A psoriasis vulgaris protective gene maps close to the HLA-C locus on the EH18.2-extended haplotype.
|
15191522 |
2004 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The alpha-helix coiled-coil rod homologue (HCR) gene, located 110 kb telomeric to the HLA-C locus, is presumed to be one of the PV candidate genes.
|
15214895 |
2004 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Correlation of HLA-Cw*06 allele frequency with some clinical features of psoriasis vulgaris in the population of northern Poland.
|
15523160 |
2004 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-Cw*0304 (5.07% vs. 14.43%, Pc < 1 x 10(-3)), -DQA1*0501 (5.79% vs. 14.09%, Pc < 0.05) were found to be negatively associated with PV, but HLA-A*2 (2.54% vs. 6.38%, Pc < 0.5) was decreased in PV patients without statistical significance.
|
15245541 |
2004 |
Psoriasis vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results show conclusively that psoriasis vulgaris and guttate psoriasis have a similar genetic basis for their association to PSORS1, whereas palmoplantar pustulosis appears to be a distinct disorder.
|
12648227 |
2003 |
Psoriasis vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
Association of psoriasis vulgaris with HLA-C is not equally strong in different human populations.
|
12505198 |
2003 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SPR1 gene, a predicted gene located 128 kb telomeric to the HLA-C locus, is considered to be one potential candidate gene of PV.
|
12823445 |
2003 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Psoriasis vulgaris and psoriatic arthritis share a 100 kb susceptibility region telomeric to HLA-C.
|
12730526 |
2003 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As serotyping has proved to be less valuable in the determination of HLA-C, genotyping of HLA-C in 68 Taiwanese psoriasis vulgaris (PSV) patients was performed using polymerase chain reaction/sequence-specific oligonucleotide probe hybridization (PCR-SSOPH) of HLA-Cw genes.
|
12115024 |
2002 |
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms in the cell growth regulated gene, SC1 telomeric of the HLA-C gene and lack of association of psoriasis vulgaris.
|
10777095 |
2000 |
Psoriasis vulgaris
|
0.100 |
Biomarker
|
disease |
BEFREE |
As we reported previously, HLA-C molecules are assumed to play a more important part than HLA-DM genes in the development of psoriasis vulgaris.
|
10417524 |
1999 |