MNX1, motor neuron and pancreas homeobox 1, 3110

N. diseases: 113; N. variants: 9
Disease: insulinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021670
Disease: insulinoma
insulinoma 		0.030 Biomarker disease BEFREE Overall, our results highlight the importance of HLXB9 in conditions of β-cell excess (insulinomas) and in conditions of β-cell loss or dysfunction (diabetes). 29309627 2018
CUI: C0021670
Disease: insulinoma
insulinoma 		0.030 Biomarker disease BEFREE GSK-3β protein phosphorylates and stabilizes HLXB9 protein in insulinoma cells to form a targetable mechanism of controlling insulinoma cell proliferation. 24425879 2014
CUI: C0021670
Disease: insulinoma
insulinoma 		0.030 Biomarker disease BEFREE Thus, upon menin loss or from other causes, dysregulation of Hlxb9 predicts a possible combined mechanism for β-cell proliferation and insulin production in insulinomas. 23419452 2013