MNX1, motor neuron and pancreas homeobox 1, 3110

N. diseases: 113; N. variants: 9
Disease: leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023418
Disease: leukemia
leukemia 		0.060 GeneticVariation disease BEFREE Nuclear Repositioning of the Non-Translocated HLXB9 Allele in the Leukaemia Cell Line GDM-1 Harbouring a t(6;7)(q23;q36). 28965118 2017
CUI: C0023418
Disease: leukemia
leukemia 		0.060 PosttranslationalModification disease BEFREE An example of this is the altered nuclear positioning of the HLXB9 gene in leukaemia cells observed in association with its over-expression. 25136833 2014
CUI: C0023418
Disease: leukemia
leukemia 		0.060 PosttranslationalModification disease BEFREE Here we investigate the role of epigenetic inactivation of the HLXB9 gene in leukemia. 21069786 2011
CUI: C0023418
Disease: leukemia
leukemia 		0.060 AlteredExpression disease BEFREE MNX1-ETV6 fusion gene in an acute megakaryoblastic leukemia and expression of the MNX1 gene in leukemia and normal B cell lines. 18940475 2008
CUI: C0023418
Disease: leukemia
leukemia 		0.060 AlteredExpression disease BEFREE The t(7;12) is associated with a poor outcome and an ectopic expression of HLXB9 is commonly involved in this genetic subtype of leukemia. 16646086 2006
CUI: C0023418
Disease: leukemia
leukemia 		0.060 AlteredExpression disease BEFREE Fluorescence in situ hybridization analysis showed chromosomal breakpoints close to the region upstream of HLXB9, at 7q36, a region rearranged in certain AML patients, and at 6q23 upstream of MYB, a gene activated in leukemia. 15540222 2005