|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
These results could be explained by increased disease heterogeneity in the noncataplexy group or by a direct effect of the HLA DQB1*0602 genotype on the clinical expression of narcolepsy.
|
9456467 |
1997 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Narcolepsy symptom severity varies in a linear manner according to HLA-DQB1*0602 allele status.
|
20120618 |
2010 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Narcolepsy is strongly associated with the HLA DQB1*0602 allele, and its symptoms stem from destruction of hypocretin-secreting neurons in the hypothalamus.
|
22213222 |
2012 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
GWASCAT |
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
|
24204295 |
2013 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
To quantify T CD4, T CD8 and B lymphocytes in subgroups of patients with narcolepsy and the presence or absence of the HLA-DQB1*0602 allele between groups.
|
17665008 |
2007 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
HLA-DQB1*0602 and HLA DRB1 alleles are closely associated with narcolepsy.
|
18345414 |
2007 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients.
|
16125818 |
2005 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In the present study, HLA-DQB1 in 664 Japanese narcoleptic subjects and 3131 Japanese control subjects was examined to determine whether HLA-DQB1 alleles located in trans of DQB1*06:02 are associated with narcolepsy.
|
25256355 |
2015 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our data add further support to the strong association of the HLA-DQB1(∗)06:02 allele with narcolepsy, especially in narcolepsy+cataplexy patients.
|
24157097 |
2013 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Narcolepsy (hypocretin deficiency), a sleep disorder characterized by sleepiness, cataplexy and rapid eye movement (REM) sleep abnormalities, is tightly associated with HLA-DRB1*1501 (M17378) and HLA-DQB1*0602 (M20432).
|
18820697 |
2008 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
This comprehensive genetic study sought to assess variations in CHKB and CPT1B susceptibility genes and HLA-DQB1*06:02 allele status in Turkish patients with narcolepsy and healthy persons.
|
24571861 |
2014 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Prevalence of the HLA-DQB1*0602 allele in narcolepsy and idiopathic hypersomnia patients seen at a sleep disorders outpatient unit in São Paulo.
|
19506770 |
2009 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Genetic studies confirmed the association with the allele HLA-DQB1*06:02, which is known to be related to sporadic narcolepsy.
|
26123389 |
2015 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Passive smoking may be a risk factor for narcolepsy in subjects with HLA DQB1*0602.
|
19039244 |
2009 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Carrying HLA-DQB1*06:02 was significantly associated with narcolepsy, odds ratio (OR) 39.4 [95% confidence interval (CI) 11.3, 137], p = 7.9 × 10<sup>-9</sup>.
|
30711515 |
2019 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DQB1*06:02 allele alone was not sufficient to cause MS patients to develop narcolepsy.
|
28658402 |
2017 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our study aimed to determine the prevalence of HLA-DQB1*0602 allele in Iranian patients with narcolepsy and assess its predictive parameters for diagnosing narcolepsy.
|
29149785 |
2017 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
For narcolepsy with HLA-DQB1 *0602, prevalence was 15.3 (95% CI: 12.8-17.9).
|
19013100 |
2009 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
The cataplectic narcolepsy differed from non-cataplectic narcolepsy by having more rapid eye movement (REM)-related clinical symptoms (more sleep paralysis and sleep-related hallucination) and sleep disturbances (shorter REM latency), as well as tighter association with HLA DQB1*0602.
|
18388176 |
2008 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
The association between narcolepsy and human leukocyte antigen HLA- DQB1*06:02 has been established elsewhere but remains to be investigated among Saudi Arabian patients with narcolepsy.
|
30187366 |
2019 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.
|
20711174 |
2010 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
The importance of HLA DQB1*0602 typing in Slovene patients with narcolepsy.
|
12097985 |
2002 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
Human narcolepsy is tightly associated with HLA-DQB1*0602; canine narcolepsy is linked with a DNA segment with high homology with the human immunoglobulin mu-switch segment, and the onset of canine narcolepsy is associated with increased microglial expression of major histocompatibility complex DQ and DR molecules.
|
9363189 |
1996 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
Increased prevalence of HLA-DQB1*0602, a marker of narcolepsy, was observed in males but not in females with > or =2 SOREMPs.
|
16597649 |
2006 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
We decided to test for the presence of several neuron-specific and organ-specific autoantibodies to see if they were present in HLA DQB1*0602-associated or cataplexy-associated narcolepsy or could serve as a serologic marker of the illness.
|
12405606 |
2002 |