|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Narcolepsy (hypocretin deficiency), a sleep disorder characterized by sleepiness, cataplexy and rapid eye movement (REM) sleep abnormalities, is tightly associated with HLA-DRB1*1501 (M17378) and HLA-DQB1*0602 (M20432).
|
18820697 |
2008 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Narcolepsy symptom severity varies in a linear manner according to HLA-DQB1*0602 allele status.
|
20120618 |
2010 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Narcolepsy is strongly associated with the HLA DQB1*0602 allele, and its symptoms stem from destruction of hypocretin-secreting neurons in the hypothalamus.
|
22213222 |
2012 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
HLA-DQB1*0602 and HLA DRB1 alleles are closely associated with narcolepsy.
|
18345414 |
2007 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
HLA DQB1*0602 is found in most individuals with hypocretin-deficient narcolepsy, a disorder characterized by a severe disruption of sleep and wake.
|
21292329 |
2011 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency.
|
25197808 |
2014 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
HLA-DQB1*0602 forms a heterodimer with HLA-DQA1*0102 and may act as an antigen presenter to the T cell receptors, resulting in narcolepsy susceptibility.
|
28108192 |
2018 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
Although narcolepsy presents one of the tightest associations with a specific human leukocyte antigen (HLA) (DQB1*0602), there is strong evidence that non-HLA genes also confer susceptibility.
|
16754256 |
2006 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
An association analysis of HLA-DQB1 with narcolepsy without cataplexy and idiopathic hypersomnia with/without long sleep time in a Japanese population.
|
27081540 |
2015 |
|
Narcolepsy
|
0.800 |
SusceptibilityMutation
|
disease |
ORPHANET |
Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1 in Mexican patients: a relationship between HLA and gender is suggested.
|
18706091 |
2008 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
Biological markers of narcolepsy with cataplexy (classical narcolepsy) include sleep-onset REM periods (SOREM) on multiple sleep latency tests (MSLT), HLA-DQB1*0602 positivity, low levels of cerebrospinal fluid (CSF) hypocretin-1 (orexin A), increased body mass index (BMI), and high levels of CSF leptin.
|
14592354 |
2003 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Carrying HLA-DQB1*06:02 was significantly associated with narcolepsy, odds ratio (OR) 39.4 [95% confidence interval (CI) 11.3, 137], p = 7.9 × 10<sup>-9</sup>.
|
30711515 |
2019 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients.
|
16125818 |
2005 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
Correlation between HLA-DQB1*06:02 and narcolepsy with and without cataplexy: approving a safe and sensitive genetic test in four major ethnic groups. A systematic meta-analysis.
|
30321823 |
2018 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Familial Kleine-Levin Syndrome: A Specific Entity?
|
27253765 |
2016 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
For narcolepsy with HLA-DQB1 *0602, prevalence was 15.3 (95% CI: 12.8-17.9).
|
19013100 |
2009 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Genetic studies confirmed the association with the allele HLA-DQB1*06:02, which is known to be related to sporadic narcolepsy.
|
26123389 |
2015 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
GWASCAT |
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
|
24204295 |
2013 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.
|
20711174 |
2010 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
Human narcolepsy is tightly associated with HLA-DQB1*0602; canine narcolepsy is linked with a DNA segment with high homology with the human immunoglobulin mu-switch segment, and the onset of canine narcolepsy is associated with increased microglial expression of major histocompatibility complex DQ and DR molecules.
|
9363189 |
1996 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In the present study, HLA-DQB1 in 664 Japanese narcoleptic subjects and 3131 Japanese control subjects was examined to determine whether HLA-DQB1 alleles located in trans of DQB1*06:02 are associated with narcolepsy.
|
25256355 |
2015 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
In this paper, we extend an analysis of the effect of HLA-DQB1 on narcolepsy risk published recently by Tafti et al.
|
25325462 |
2015 |
|
Narcolepsy
|
0.800 |
Biomarker
|
disease |
BEFREE |
Increased prevalence of HLA-DQB1*0602, a marker of narcolepsy, was observed in males but not in females with > or =2 SOREMPs.
|
16597649 |
2006 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our data add further support to the strong association of the HLA-DQB1(∗)06:02 allele with narcolepsy, especially in narcolepsy+cataplexy patients.
|
24157097 |
2013 |
|
Narcolepsy
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our study aimed to determine the prevalence of HLA-DQB1*0602 allele in Iranian patients with narcolepsy and assess its predictive parameters for diagnosing narcolepsy.
|
29149785 |
2017 |