Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.320 Biomarker disease CTD_human Apart from multiple sclerosis, which shares several susceptibility loci with other immune-related disorders, variation at HLA-DRB5 being associated both with Parkinson's disease and Alzheimer's disease, and the association of the C9orf72 repeat expansion with ALS and frontotemporal degeneration, there was little evidence of gene loci being consistently associated with more than one neurological condition or with other conditions. 27713094 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.320 GeneticVariation disease BEFREE Apart from multiple sclerosis, which shares several susceptibility loci with other immune-related disorders, variation at HLA-DRB5 being associated both with Parkinson's disease and Alzheimer's disease, and the association of the C9orf72 repeat expansion with ALS and frontotemporal degeneration, there was little evidence of gene loci being consistently associated with more than one neurological condition or with other conditions. 27713094 2017
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.320 Biomarker disease CTD_human Apart from multiple sclerosis, which shares several susceptibility loci with other immune-related disorders, variation at HLA-DRB5 being associated both with Parkinson's disease and Alzheimer's disease, and the association of the C9orf72 repeat expansion with ALS and frontotemporal degeneration, there was little evidence of gene loci being consistently associated with more than one neurological condition or with other conditions. 27713094 2017
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.320 GeneticVariation disease BEFREE Apart from multiple sclerosis, which shares several susceptibility loci with other immune-related disorders, variation at HLA-DRB5 being associated both with Parkinson's disease and Alzheimer's disease, and the association of the C9orf72 repeat expansion with ALS and frontotemporal degeneration, there was little evidence of gene loci being consistently associated with more than one neurological condition or with other conditions. 27713094 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.320 Biomarker disease BEFREE In the present study, we try to review the inflammation in AD and immunity-associated GWAS risk genes like HLA-DRB5/DRB1, INPP5D, MEF2C, CR1, CLU and TREM2. 26232392 2015
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.320 GeneticVariation disease BEFREE Two genome-wide association studies (GWASs) recently highlighted the HLA-DRA and HLA-DRB5 genes as associated with Parkinson disease (PD). 22807207 2012
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.310 Biomarker disease CTD_human We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). 28869590 2017
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.310 GeneticVariation disease BEFREE We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). 28869590 2017
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.310 Biomarker disease CTD_human Genetic variation associated with the occurrence and progression of neurological disorders. 27713094 2017
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
Alzheimer Disease, Late Onset 		0.310 GeneticVariation disease BEFREE Of these, rs2516049 (closest gene HLA-DRB5; conjunction false discovery rate P = .04 for AD and psoriasis, 5.37 × 10-5 for AD, and 6.03 × 10-15 for psoriasis) and rs12570088 (closest gene IPMK; conjunction false discovery rate P = .009 for AD and Crohn disease, P = 5.73 × 10-6 for AD, and 6.57 × 10-5 for Crohn disease) demonstrated the same direction of allelic effect between AD and the immune-mediated diseases. 27088644 2016
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.300 Biomarker disease CTD_human Genetic variation associated with the occurrence and progression of neurological disorders. 27713094 2017
CUI: C0276496
Disease: Familial Alzheimer Disease (FAD)
Familial Alzheimer Disease (FAD) 		0.300 Biomarker disease CTD_human Genetic variation associated with the occurrence and progression of neurological disorders. 27713094 2017
CUI: C0546126
Disease: Acute Confusional Senile Dementia
Acute Confusional Senile Dementia 		0.300 Biomarker disease CTD_human Genetic variation associated with the occurrence and progression of neurological disorders. 27713094 2017
CUI: C0750900
Disease: Alzheimer's Disease, Focal Onset
Alzheimer's Disease, Focal Onset 		0.300 Biomarker disease CTD_human Genetic variation associated with the occurrence and progression of neurological disorders. 27713094 2017
CUI: C0750901
Disease: Alzheimer Disease, Early Onset
Alzheimer Disease, Early Onset 		0.300 Biomarker disease CTD_human Genetic variation associated with the occurrence and progression of neurological disorders. 27713094 2017
CUI: C0020517
Disease: Hypersensitivity
Hypersensitivity 		0.300 Biomarker group CTD_human [Analysis of a genetic factor of metal allergy--polymorphism of HLA-DR, -DQ gene]. 8725357 1996
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		0.300 Biomarker phenotype CTD_human [Analysis of a genetic factor of metal allergy--polymorphism of HLA-DR, -DQ gene]. 8725357 1996
CUI: C0004096
Disease: Asthma
Asthma 		0.110 GeneticVariation disease GWASCAT Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. 30929738 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.110 Biomarker disease BEFREE The chromosome conformation capture (3C) analysis in human brain cells revealed the architecture of multipoint chromatin interactions between the schizophrenia-associated genetic and epigenetic polymorphic sites and distantly located HLA-DRB5 and BTNL2 genes. 31624234 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.110 GeneticVariation disease GWASCAT Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. 28540026 2017
CUI: C0004096
Disease: Asthma
Asthma 		0.110 Biomarker disease BEFREE The findings are consistent with an MHC-linked gene or genes on [HLA-B7, SC31, DR2] (but not necessarily DR2, Dw2, or DQw6 in general) controlling the IgE immune response to Amb a V and associated with asthma in ragweed pollen-sensitive subjects. 1729361 1992
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.100 GeneticVariation disease BEFREE HLA-DR15 haplotypes, including genomic variants of HLA-DRB5, and HLA-DR4 haplotypes affect MS risk. 29683085 2019
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement 		0.100 GeneticVariation phenotype GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
CUI: C0008074
Disease: Child Development Disorders, Pervasive
Child Development Disorders, Pervasive 		0.100 GeneticVariation group GWASCAT Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. 28540026 2017
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.100 GeneticVariation disease GWASCAT Discovery of susceptibility loci associated with tuberculosis in Han Chinese. 29036319 2017