|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
A gene region close to the human leukocyte antigen-G (HLA-G) gene was identified as an independent susceptibility marker for asthma.
|
30142579 |
2018 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Individual variation in HLA-G expression is linked to its genetic polymorphism and has been associated with many pathological situations such as asthma, which is characterized by epithelium abnormalities and inflammatory cell activation.
|
29527207 |
2018 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
HLA-G protein expression and genetic polymorphisms have been reported to be associated with asthma.
|
28303134 |
2017 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These microRNAs suppress HLA-G expression, and rs1063320, a common SNP in the HLA-G 3'UTR that is associated with asthma risk, modulates miRNA binding.
|
25266681 |
2015 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
These combined results are consistent with +3142 allele-specific targeting of HLA-G by the miR-152 family and support our hypothesis that miRNA regulation of sHLA-G in the airway is influenced by both the asthma status of the subject's mother and the subject's genotype.
|
23534973 |
2013 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
As the NK cell receptor KIR2DL4 has been reported to induce interferon gamma (IFNγ) secretion when ligated with HLA-G, we postulated that the 9A/10A genetic polymorphism of KIR2DL4 which influences receptor structure may influence susceptibility to asthma.
|
24033084 |
2013 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We found that DPP10 was significantly associated with bronchial hyperresponsiveness (BHR) and BHR asthma after the adjustment for multiple testing; while the associations of PHF11 with positive skin reactions to antigens and the associations of HLA-G with BHR asthma were only nominally significant.
|
19951440 |
2009 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.
|
17847008 |
2007 |
|
Asthma
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.
|
17847008 |
2007 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We identified HLA-G as an asthma susceptibility gene in multiple populations and demonstrated that variation in this gene influences subsequent risk for asthma.
|
16257632 |
2005 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we present evidence from four independent samples in support of HLA-G as a novel asthma and bronchial hyperresponsiveness susceptibility gene in the human leukocyte antigen region on chromosome 6p21, and we speculate that this gene might contribute to risk for other inflammatory diseases that show linkage to this region.
|
15611928 |
2005 |
|
Asthma
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Asthma
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
BEFREE |
Our findings further support the genetic contribution of HLA-G to BD risk, as well as indicate relevant expression profiles.
|
29737889 |
2018 |
|
Bipolar Disorder
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed.
|
23246584 |
2013 |
|
Bipolar Disorder
|
0.320 |
Biomarker
|
disease |
PSYGENET |
Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed.
|
23246584 |
2013 |
|
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine the possible associations of soluble HLA-G and HLA-G +3142G/C SNP with breast cancer.
|
31759373 |
2019 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
The found results indicate that HLA-G may play an important role in the breast cancer.
|
30945586 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The implication of HLA-G in cancer development has been reported in different cancers and populations.
|
31759373 |
2019 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
HLA-G expression in cancer cells can directly mediate immune tolerance by interacting with inhibitory receptors such as ILT2 and ILT4 expressed on immune cells.
|
31489189 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The origin of HLA-G was linked to inflammatory cytokines present in the cancer microenvironment.
|
30802770 |
2019 |
|
Choriocarcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Considering the immunomodulatory properties of Aire and HLA-G, and considering that the role of the constitutive thymus expression of HLA-G has not been elucidated, we studied the effect of AIRE cDNA transfection on HLA-G expression in 4D6 thymic cells and in the HLA-G-positive JEG-3 choriocarcinoma cells.
|
31322727 |
2019 |
|
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This activity is independent of MHC class-I mediated inhibition via KIR2DL1, but dependent upon the interaction between NK cell-expressed KIR2DL4 and its oligodendrocyte-expressed ligand, HLA-G. NK cells from patients with MS express higher levels of IFN-γ following conjugation to OLs, more actively promote in vitro reduction of MOG and MAG and have higher frequencies of the KIR2DL4 positive population.
|
30482463 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Herein, we discuss the relative aspects of the intercellular transfer of HLA-G between tumor cells and immune cells and its potential use in tumor immunology research and translational cancer therapy.
|
31489189 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The present study focuses on the influence of the tumor microenvironment on the expression of HLA-G in ovarian cancer and its impact on immune cells.
|
30802770 |
2019 |