HMGB2, high mobility group box 2, 3148

N. diseases: 59; N. variants: 0
Disease: Degenerative polyarthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.040 Biomarker disease BEFREE High mobility group protein B2 (HMGB2) is an important protein attributed to tissue function and homeostasis in osteoarthritis (OA), however, its roles in the temporomandibular joint with mechanical pressure are unclear. 31629102 2020
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.040 AlteredExpression disease BEFREE Given the similar expression and activation patterns of HMGB2 and β-catenin in articular cartilage, the loss of these pathways in the SZ of articular cartilage may lead to altered gene expression, cell death and OA-like pathogenesis. 28916968 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.040 AlteredExpression disease BEFREE HMGB2 was down-regulated in human OA-affected cartilage. 24905701 2014
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.040 Biomarker disease BEFREE Mice genetically deficient in HMGB2 (Hmgb2(-/-)) show earlier onset of and more severe OA. 19139395 2009