DisGeNET - a database of gene-disease associations

HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase, 3156

N. diseases: 154; N. variants: 15

Disease: Kidney Failure, Chronic ×

Source: ALL

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C0022661
Disease:	Kidney Failure, Chronic

Kidney Failure, Chronic

0.500

Biomarker

disease

RGD

Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin.

21119529

2011

CUI:	C0022661
Disease:	Kidney Failure, Chronic

Kidney Failure, Chronic

0.500

Biomarker

disease

CTD_human

Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.

19878707

2010