|
Breast Carcinoma
|
0.490 |
Biomarker
|
disease |
BEFREE |
This study demonstrates a novel role of RHAMM in cell migration in luminal A breast cancer and suggests that therapeutic strategies involving RHAMM should be considered for various subtypes of breast cancer.
|
31769593 |
2019 |
|
Breast Carcinoma
|
0.490 |
Biomarker
|
disease |
BEFREE |
Combined, the effects of HMMR and SDC1 showed a significant correlation with poor OS for patients with breast cancer (high expression for both HMMR and SDC1: [aHR] 3.29, 95%CI=1.52-7.12, p=0.003).
|
30061226 |
2018 |
|
Breast Carcinoma
|
0.490 |
Biomarker
|
disease |
BEFREE |
Here, we report a novel role for the breast cancer susceptibility gene and microtubule (MT) binding protein Hmmr (Hyaluronan-mediated motility receptor, RHAMM) in anterior neurulation and forebrain development in Xenopus laevis.
|
28778799 |
2017 |
|
Breast Carcinoma
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
The association of HMMR rs299290 with breast cancer risk in BRCA1 mutation carriers was confirmed: per-allele hazard ratio (HR) = 1.10, 95% confidence interval (CI) 1.04-1.15, p = 1.9 x 10(-4) (false discovery rate (FDR)-adjusted p = 0.043).
|
25830658 |
2015 |
|
Breast Carcinoma
|
0.490 |
Biomarker
|
disease |
BEFREE |
Accordingly, selective siRNA-mediated knockdown of HMMR in breast cancer cells substantially reduces the invasion and migration of cells.
|
22203674 |
2012 |
|
Breast Carcinoma
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Starting from complementary genetic analyses across families and populations, we identified common genetic variation at the low-penetrance susceptibility HMMR locus (encoding for RHAMM) that modifies breast cancer risk among BRCA1, but probably not BRCA2, mutation carriers: n = 7,584, weighted hazard ratio ((w)HR) = 1.09 (95% CI 1.02-1.16), p(trend) = 0.017; and n = 3,965, (w)HR = 1.04 (95% CI 0.94-1.16), p(trend) = 0.43; respectively.
|
22110403 |
2011 |
|
Breast Carcinoma
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
We have examined the association of these single nucleotide polymorphisms, together with others tagging the HMMR gene, in a larger, European case-control study and find no association of any of them with risk of breast cancer: rs10515860 [odds ratio (OR; AA/GG), 0.85; 95% confidence interval (CI), 0.65-1.12; P(trend) = 0.9], rs299290 [OR (CC/TT), 1.00; 95% CI, 0.87-1.15; P(trend) = 0.7], rs3756648 (rs7712023) [OR (TT/CC), 0.93; 95% CI, 0.84-1.02; P(trend) = 0.1], rs299284 [OR (TT/CC), 1.01; 95% CI, 0.76-1.35; P(trend) = 0.5], and rs13183712 [OR (TT/GG), 1.04; 95% CI, 0.88-1.23; P(trend) = 0.6].
|
19064580 |
2008 |
|
Breast Carcinoma
|
0.490 |
Biomarker
|
disease |
CTD_human |
Two case-control studies of incident breast cancer indicate that the HMMR locus is associated with higher risk of breast cancer in humans.
|
17922014 |
2007 |
|
Breast Carcinoma
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Two case-control studies of incident breast cancer indicate that the HMMR locus is associated with higher risk of breast cancer in humans.
|
17922014 |
2007 |
|
Breast Carcinoma
|
0.490 |
AlteredExpression
|
disease |
BEFREE |
Western blotting stained positive for RHAMM protein in 70% of AML patients. mRNA expression of RHAMM also was found in patients with CML (40%), renal cell carcinoma (73%), breast carcinoma (60%), and ovarian carcinoma (50%).
|
12225794 |
2002 |
|
Breast Carcinoma
|
0.490 |
Biomarker
|
disease |
HPO |
|
|
|