FOXA1, forkhead box A1, 3169

N. diseases: 138; N. variants: 1
Disease: Carcinoma of bladder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.060 PosttranslationalModification disease BEFREE In addition, FOXA1 is hypermethylated in basal bladder cancer cell lines, and this is reversed by treatment with DNA methyltransferase inhibitors. 31636388 2020
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.060 AlteredExpression disease BEFREE Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS. 30670749 2019
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.060 Biomarker disease BEFREE Studies also implicate FOXA2 in bladder cancer and several other FOX proteins might be involved in development and/or progression of this disease; for example, FOXA1 and FOXO3A have been associated with clinical patient outcomes. 27898096 2017
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.060 GeneticVariation disease BEFREE FOXA1 and CK14 as markers of luminal and basal subtypes in histologic variants of bladder cancer and their associated conventional urothelial carcinoma. 28721490 2017
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.060 Biomarker disease BEFREE FOXA1, GATA3 and PPARɣ Cooperate to Drive Luminal Subtype in Bladder Cancer: A Molecular Analysis of Established Human Cell Lines. 27924948 2016
CUI: C0699885
Disease: Carcinoma of bladder
Carcinoma of bladder 		0.060 AlteredExpression disease BEFREE MicroRNA-99a and 100 mediated upregulation of FOXA1 in bladder cancer. 25071007 2014