|
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to explore the influence of miR-937 on breast cancer regulation of APAF1 expression.
|
31410016 |
2019 |
|
Seizures
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Western blotting was used to further analyse the expression of Apaf-1, caspase-9, caspase-3, Bcl-2, Bid, Bax, cleaved caspase-3 and cytochrome c. The results showed that compared to the those of the PTZ group, FA pre-treatment significantly (p < 0.01) reduced the Racine scores starting at day 4, prolonged the latency of the onset of seizure at day 28, reduced the escape latency period starting at day 2, increased the frequency of crossing the platform location, increased the SOD activity, reduced the MDA content and apoptosis percentage, and upregulated the Bcl-2 levels whilst downregulating the Bax, cytochrome c, Apaf-1, caspase-9, caspase-3, cleaved caspase-3 and Bid expression levels.
|
31404716 |
2019 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to explore the influence of miR-937 on breast cancer regulation of APAF1 expression.
|
31410016 |
2019 |
|
Solitary fibrous tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study suggests that dysfunction of TP53 and APAF1 leads to impaired apoptotic function, and eventually contributes toward malignant SFT transformation.
|
31321477 |
2019 |
|
Leukemia, B-Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Signal transduction mechanism studies indicated that exposure to Cu-NPs activated caspases 3, 8, and 9 and BH3 interacting domain death agonist (tBid), reduced B cell leukemia/lymphoma 2 (Bcl-2) expression, and increased the expression of apoptotic peptidase activating factor 1 (Apaf-1), BCL2-associated X, apoptosis regulator (Bax), and cytochrome c. A microarray analysis revealed significant alterations in the expression of 963 genes; of these, 622 were upregulated and 341 were downregulated.
|
30556269 |
2019 |
|
Neural Tube Defects
|
0.010 |
Biomarker
|
group |
BEFREE |
Key apoptotic genes APAF1 and CASP9 implicated in recurrent folate-resistant neural tube defects.
|
29358613 |
2018 |
|
Periodontitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
An increased proteic expression of APAF-1 was also observed in a murine experimental periodontitis model induced by P. gingivalis-soaked ligatures.
|
29154960 |
2018 |
|
Squamous cell carcinoma of skin
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
An miR-186 binding site was predicted in APAF1 and their expression was negatively correlated in cSCC tissues.
|
30344679 |
2018 |
|
Rheumatoid Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Following identification of potential mir-155 target transcripts by bioinformatic methods, we show increased levels of mature mir-155 expression in RA PBM and SFM vs. HC PBM and a corresponding decrease in SFM of two predicted mir-155-target mRNAs, apoptosis mediators CASP10 and APAF1.
|
28118944 |
2017 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our findings present the first piece of evidence indicating the interaction between Apaf-1 and procaspase-9 as a novel therapeutic target in myocardial infarction and suggesting ZYZ-488 as a promising therapeutic option for myocardial infarction disease.
|
29279737 |
2017 |
|
Laryngeal Squamous Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-221 can be considered as a diagnostic marker in LSCC and Apaf-1 may be considered as a possible target of miR-221.
|
28453462 |
2017 |
|
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the APAF1 gene was confirmed as a direct target of miR-221 and overexpression of APAF1 suppressed ovarian cancer cell proliferation and induced cell apoptosis in vitro.
|
28350128 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the APAF1 gene was confirmed as a direct target of miR-221 and overexpression of APAF1 suppressed ovarian cancer cell proliferation and induced cell apoptosis in vitro.
|
28350128 |
2017 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our results implicate Apaf-1 mislocalization as a potential diagnostic and prognostic marker for DLBCL, and provide a novel therapeutic strategy for circumventing the drug refractory nature of this sub-class of B cell lymphoma.
|
27863378 |
2016 |
|
Squamous cell carcinoma of the head and neck
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Our results can show that the promoter region of apoptotic protease activating factor 1 (Apaf-1) was not methylated in the HNSCC cell lines.
|
27038158 |
2016 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, our data provided evidence that increased Rack1-mediated upregulation of PKC kinase activity may be responsible for the development of chemoresistance in T-ALL-derived cell line potentially by reducing FEM1b and Apaf-1 level.
|
27644318 |
2016 |
|
Chlamydia Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Interestingly, caspase-9 in apaf-1 (-/-) MEFs was activated by chlamydial infection but during the infection caspase-3 was not activated.
|
26290316 |
2015 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
It is suggested that miR-23a, acting as an oncogenic regulator by directly targeting APAF 1 in pancreatic cancer, is a useful potential biomarker in diagnosis and treatment of pancreatic cancer.
|
25701323 |
2015 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
It is suggested that miR-23a, acting as an oncogenic regulator by directly targeting APAF 1 in pancreatic cancer, is a useful potential biomarker in diagnosis and treatment of pancreatic cancer.
|
25701323 |
2015 |
|
MSI-low
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The ITH of mutations in the mononucleotide repeats of APAF1, BAX and FLASH in different tumors were analyzed in 16 cases of CRC with high microsatellite instability (MSI-H) and 41 cases of CRC with stable MSI/low MSI (MSS/MSI-L) by single-strand conformation polymorphism and DNA sequencing analyses.
|
25599959 |
2015 |
|
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Amyloid β binds procaspase-9 to inhibit assembly of Apaf-1 apoptosome and intrinsic apoptosis pathway.
|
24424093 |
2014 |
|
Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, intracellular Bcl-2 protein expression was effectively reduced in 143B-harbored tumor tissue through western blotting analysis (P<0.01), while intratumoral Apaf-1 and cleaved Caspase-3 protein levels were up-regulated, respectively (P<0.01).
|
24797937 |
2014 |
|
Osteosarcoma of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, intracellular Bcl-2 protein expression was effectively reduced in 143B-harbored tumor tissue through western blotting analysis (P<0.01), while intratumoral Apaf-1 and cleaved Caspase-3 protein levels were up-regulated, respectively (P<0.01).
|
24797937 |
2014 |
|
Childhood Osteosarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, intracellular Bcl-2 protein expression was effectively reduced in 143B-harbored tumor tissue through western blotting analysis (P<0.01), while intratumoral Apaf-1 and cleaved Caspase-3 protein levels were up-regulated, respectively (P<0.01).
|
24797937 |
2014 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of the apoptotic protease activating factor-1 (APAF1), which might be one of the direct targets of miR-23a, was also analyzed using the luciferase reporter assay and western blot analysis in 293T cells and glioma cell line, respectively.
|
23865473 |
2013 |