|
Hematologic Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Furthermore, in silico analyses of public transcriptomics databases indicated elevated Apaf-1 expression in several hematologic malignancies, including acute lymphoblastic and myeloid leukemia.
|
23093495 |
2013 |
|
Carcinoma of urinary bladder, superficial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We examined the expression of anti-apoptotic genes (XIAP and Bcl-2) and apoptotic genes (cytochrome c, caspase-9, Apaf-1) in tissue samples of patients with superficial bladder cancer.
|
23613234 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also noted variable Apaf-1 expression in a panel of samples from patients with acute lymphoblastic leukemia.
|
23093495 |
2013 |
|
Lysinuric Protein Intolerance
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overloading HK-2 with Lysine levels reproducing those observed in urine of patients affected by LPI (10 mM) increased apoptosis (+30%; p < 0.01 vs.C), as well as Bax and Apaf-1 expressions (+30-50% p < 0.05), while downregulated Bcl-2 (-40% p < 0.05).
|
22403019 |
2012 |
|
Myelodysplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of APAF-1 in low-risk myelodysplastic syndrome: a possible role in the pathophysiology of myelodysplasia.
|
20345447 |
2010 |
|
Miller Dieker syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to characterize the mRNA expression levels of APAF-1 transcripts in low-risk and high-risk MDS and to elucidate whether the expression levels of APAF-1 transcripts are modulated with increased apoptosis in CD34(+) MDS cells undergoing erythroid differentiation.
|
20345447 |
2010 |
|
Childhood Myelodysplastic Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of APAF-1 in low-risk myelodysplastic syndrome: a possible role in the pathophysiology of myelodysplasia.
|
20345447 |
2010 |
|
MYELODYSPLASTIC SYNDROME
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Increased expression of APAF-1 in low-risk disease and its positive correlation with the apoptotic rate observed during the erythroblast differentiation of low-risk MDS cells may indicate that the modulation of APAF-1, at the transcriptional level, participates in the pathophysiology of MDS.
|
20345447 |
2010 |
|
Adult Myelodysplastic Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of APAF-1 in low-risk myelodysplastic syndrome: a possible role in the pathophysiology of myelodysplasia.
|
20345447 |
2010 |
|
Acute Promyelocytic Leukemia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
DAP kinase methylation was detected in four (16%) ALL patients. p14 and Apaf-1 methylation was not detected in any of the 32 cases of acute promyelocytic leukaemia (APL), 50 cases of other subtypes of acute myeloid leukaemia (AML), and 25 cases of acute lymphoblastic leukaemia.
|
18587015 |
2008 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Immunohistochemistry for Apaf-1 was performed on the tissue microarray of 38 normal mucosal tissues, 46 adenomatous polyps, 529 colorectal adenocarcinomas, and 76 metastatic tumors.
|
17882496 |
2007 |
|
Blast Phase
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
To conclude, in this study we have demonstrated mRNA elevation of p53 and apaf1 during CML blast crisis, indicating that genes and proteins involved in cellular apoptosis might be involved in disease progression/response to therapy.
|
17361096 |
2007 |
|
Blast Phase
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Apaf1 in chronic myelogenous leukemia (CML) progression: reduced Apaf1 expression is correlated with a H179R p53 mutation during clinical blast crisis.
|
17361096 |
2007 |
|
Brain Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
ChIP assays reveal that E2F1 binds the Apaf-1 promoter specifically in tumor tissue, suggesting that E2F1 contributes to the expression of Apaf-1 in brain tumors.
|
18093951 |
2007 |
|
Colorectal Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Modification of gene products involved in resistance to apoptosis in metastatic colon cancer cells: roles of Fas, Apaf-1, NFkappaB, IAPs, Smac/DIABLO, and AIF.
|
17603079 |
2007 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of Apaf-1 mRNA in gastric cancer tissue samples was 51%.
|
17876870 |
2007 |
|
Stomach Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Rationales for expression and altered expression of apoptotic protease activating factor-1 gene in gastric cancer.
|
17876870 |
2007 |
|
Transitional cell carcinoma of bladder
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
EZH2 polycomb transcriptional repressor expression correlates with methylation of the APAF-1 gene in superficial transitional cell carcinoma of the bladder.
|
17541304 |
2007 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of Apaf-1 mRNA in gastric cancer tissue samples was 51%.
|
17876870 |
2007 |
|
Lymphocytic infiltration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of APAF-1, E-cadherin and peritumoral lymphocytic infiltration in tumour budding in colorectal cancer.
|
17516584 |
2007 |
|
CML progression
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Apaf1 in chronic myelogenous leukemia (CML) progression: reduced Apaf1 expression is correlated with a H179R p53 mutation during clinical blast crisis.
|
17361096 |
2007 |
|
Tumour budding
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of APAF-1, E-cadherin and peritumoral lymphocytic infiltration in tumour budding in colorectal cancer.
|
17516584 |
2007 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The expression of Apaf-1, procaspase-9 and -6 mRNAs was higher in lung adenocarcinomas as compared to squamous cell lung carcinomas but the expression levels of the studied apoptosome pathway-related transcripts in the tumours were independent of tumour's grade and stage.
|
16231180 |
2006 |
|
Kidney Neoplasm
|
0.010 |
PosttranslationalModification
|
disease |
LHGDN |
Methylation of tumour suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer.
|
17133271 |
2006 |
|
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
cDNA array analysis showed that cyclin B1, MCM5, MCM7, RAD9, ubiquitin C, CDK6, SKP2, and APAF1 were up-regulated in malignant thyroid neoplasms.
|
16547620 |
2006 |