Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
This study was aimed to assess the association of the two single nucleotide polymorphisms (SNPs) near P2 promoter (rs1884614 and rs2144908) of hepatocyte nuclear factor-4alpha (HNF4A) with insulin secretion index and type 2 diabetes in Thais.
|
17805472 |
2007 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
HNF1A is a gene coding for the transcription factor HNF1-α, mutated in some forms of MODY and type 2 diabetes mellitus characterized by a strong genetic component.
|
30963309 |
2019 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
Biomarker
|
disease |
BEFREE |
Subjects with MODY as well as those with type 2 diabetes are characterized by obesity and hyperinsulinemia.
|
20621032 |
2010 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Considering a strong association between human HNF4A polymorphisms and increased risk of type 2 diabetes our current findings suggest that downregulation of AGXT2 and subsequent impairment in metabolism of dimethylarginines and BAIB caused by HNF4α deficiency might contribute to development of cardiovascular complications in diabetic patients.
|
27752141 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Prolonged episodes of hypoglycaemia in HNF4A-MODY mutation carriers with IGT. Evidence of persistent hyperinsulinism into early adulthood.
|
27552834 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
We review recent studies that suggest that common MODY gene variation contributes modestly to the heritability of type 2 diabetes.
|
17425917 |
2007 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, a rare, novel mutation that disrupts a protein binding site in the pancreatic HNF4A promoter associates with late-onset diabetes.
|
16731855 |
2006 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, subjects with HNF4 alpha P2 variants and haplotypes have been shown to have a higher insulin resistance and are therefore at a higher risk for developing type 2 diabetes mellitus.
|
21633728 |
2011 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
Biomarker
|
disease |
BEFREE |
In conclusion, mutations in HNF-1beta and DCoH are not a major cause of MODY or late onset type 2 diabetes in Danish Caucasian subjects.
|
11668623 |
2001 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
This mutation was also identified in another proband from the autosomal dominant T2D family without mutation in known MODY genes and was segregated with diabetes.
|
29767246 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Several studies have identified evidence for linkage between type 2 diabetes and the regions on chromosomes 12 and 20 containing the maturity-onset diabetes of the young (MODY) genes, hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-4alpha.
|
10690901 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
Biomarker
|
disease |
BEFREE |
Here, we profiled metabolites in serum from patients with MODY1 (HNF4A), MODY2 (GCK), MODY3 (HNF1A), and type 2 diabetes and from healthy individuals to characterize metabolic perturbations caused by specific mutations.
|
23139355 |
2013 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to determine the prevalence of the most common MODY genes in Italian families with early-onset Type II (non-insulin-dependent) diabetes mellitus.
|
11692182 |
2001 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The maturity-onset diabetes of the young (MODY), an autosomal dominant form of non-insulin dependent diabetes mellitus (NIDDM), is caused by mutations in the glucokinase (GK, MODY 2) and in the hepatocyte nuclear factor 1a (MODY 3) and 4a (MODY 1) genes.
|
10694920 |
1998 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that common variants in several MODY genes play a modest role in type 2 diabetes susceptibility.
|
16936201 |
2006 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Effect of common polymorphisms in the HNF4alpha promoter on susceptibility to type 2 diabetes in the French Caucasian population.
|
15735892 |
2005 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The results of this study provide evidence that variants in both the P1 and P2 promoters of HNF4A increase risk for typical type 2 diabetes.
|
15561969 |
2004 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Finally, the example of single gene diabetes, particularly HNF1A MODY and permanent neonatal diabetes associated with the KCNJ11 and ABCC8 genes, all efficiently controlled on sulfonylurea, inspires us to continue the efforts to tailor individual treatment for T2DM patients.
|
22996131 |
2012 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
Our results and the independent observation of association of SNPs near the P2 promoter with diabetes in a separate study population of Ashkenazi Jewish origin suggests that variant(s) located near or within HNF4A increases susceptibility to type 2 diabetes.
|
15047633 |
2004 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
Biomarker
|
disease |
BEFREE |
Genetic abnormalities in HNF4A and HNF1A lead to a dual phenotype of HH in the newborn period and maturity onset-diabetes later in life.
|
25733449 |
2015 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
The study included 220 affected subjects from 29 families in which early-onset type 2 diabetes occurred in multiple generations and was not linked to known MODY genes (MODY gene-negative families).
|
10333942 |
1999 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
Biomarker
|
disease |
BEFREE |
We screened all 10 exons specific for the pancreatic isoform of glucokinase (1a and 2-10) including the intron flanking regions in 722 subjects (in 12 patients with an unrecognised type of MODY and their 10 family members, 313 patients with diabetes mellitus type 2 (DM2), 141 gestational diabetics (GDM), 130 healthy offspring of diabetic parents, and 116 healthy controls without family history of DM2).
|
18271687 |
2008 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
We combined these results with our previous studies on HNF4alpha and TCF1 and explicitly tested for gene-gene interactions among these variants and with several known type 2 diabetes susceptibility loci, and we found no genetic interactions between these six genes.
|
17327436 |
2007 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
During the course of our search for susceptibility genes contributing to the more common late-onset NIDDM forms, we observed nominal evidence for linkage between NIDDM and markers in the region of the HNF-4alpha/MODY1 locus in a subset of French families with NIDDM diagnosed before 45 yr of age.
|
9449683 |
1998 |
Diabetes Mellitus, Non-Insulin-Dependent
|
1.000 |
GeneticVariation
|
disease |
BEFREE |
We recommend inclusion of exon 1E and nearby DNA sequences in screening for HNF4alpha mutations and polymorphisms in genetic analyses of MODY1 and T2DM.
|
19353766 |
2009 |