|
Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the precise role of T cell factors/lymphoid enhancer-binding factor (TCFs/LEF) family members, which are the major binding complex of β-catenin, in OS is poorly understood.
|
31595984 |
2020 |
|
Osteosarcoma of bone
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the precise role of T cell factors/lymphoid enhancer-binding factor (TCFs/LEF) family members, which are the major binding complex of β-catenin, in OS is poorly understood.
|
31595984 |
2020 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the precise role of T cell factors/lymphoid enhancer-binding factor (TCFs/LEF) family members, which are the major binding complex of β-catenin, in OS is poorly understood.
|
31595984 |
2020 |
|
Atrial Fibrillation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Bleeding complications during warfarin therapy in patients with mechanical heart valves were associated with HNF4A polymorphisms and atrial fibrillation.
|
31461081 |
2019 |
|
pathologic fistula
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
To determine the frequency and risk factors that lead to the development of persistent TCF (tracheocutaneous fistula) formation in children following tracheostomy decannulation at our institution.
|
31299421 |
2019 |
|
Gastrointestinal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In this review, we will update our current understanding on the role of HNF4α in human liver and gastrointestinal diseases.
|
31435165 |
2019 |
|
Hepatitis, Alcoholic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis.
|
31311938 |
2019 |
|
Hepatolenticular Degeneration
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Functional annotation revealed that WD-hypermethylated liver DMRs were enriched in liver-specific enhancers, flanking active liver promoters, and binding sites of liver developmental transcription factors, including Hepatocyte Nuclear Factor 4 alpha (HNF4A), Retinoid X Receptor alpha (RXRA), Forkhead Box A1 (FOXA1), and FOXA2.
|
30709419 |
2019 |
|
Ketosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Most interestingly, several candidate genes, including previously reported genes (BMP4, HNF4A and APOBR) and newly identified genes (SOCS4, GCH1, ATG14, RGS6, CYP7A1 and MAPK3), are involved in insulin metabolism or lipid metabolism, implicating the contribution of energy-metabolism-associated genes to the genetic basis of KET.
|
31179571 |
2019 |
|
Cystic kidney
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A cross-sectional study of patients referred for HNF1B-MODY genetic testing due to cystic kidneys and diabetes.
|
31825128 |
2019 |
|
Polycystic Ovary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, it remains unclear whether HNF-4α is indirectly involved in the pathogenesis of PCOS via regulation of hepatic SHBG synthesis.
|
31525346 |
2019 |
|
Retinoblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Flow cytometry assay then determined that TCF over-expression helps HCC cell G1/S phase transition, and further research showed that TCF19 up-regulation inhibits p57Kip2, p21Cip1 and p27Kip1 cell cycle suppressors, enhances the expression of cyclin D1 expression and simulates retinoblastoma (Rb), FOXO1 and AKT phosphorylation.
|
30509085 |
2019 |
|
Liver Failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results indicate the role of HNF4α in LR and have implications for therapy of liver failure.
|
30520062 |
2019 |
|
Hamman-Rich syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The purposes of the present study are to report the frequency and distribution of HNF4α-expressing cells at the different airway levels, and to investigate the potential significance of the expression of HNF4α in the histogenesis of non-TRU LADC with a special reference to the relationship to bronchiolar metaplasia in idiopathic interstitial pneumonia.
|
30848476 |
2019 |
|
Gastrointestinal Stromal Tumors
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The research demonstrated that NR2A1 polymorphisms may act as contributors of IM pharmacokinetics and responses in Chinese GIST patients.
|
31045869 |
2019 |
|
Iatrogenic hyperinsulinism
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We therefore determined the relative contributions of hyperglycemia and iatrogenic hyperinsulinemia to insulin resistance using hyperinsulinemic-euglycemic clamps in three participant groups (<i>n</i> = 10/group) with differing insulinemia and glycemia: healthy control subjects (euinsulinemia and euglycemia), glucokinase-maturity-onset diabetes of the young (GCK-MODY; euinsulinemia and hyperglycemia), and type 1 diabetes (hyperinsulinemia and hyperglycemia matching GCK-MODY).
|
31092478 |
2019 |
|
Adenocarcinoma of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the role of HNF4α in pancreatic adenocarcinoma (PDAC) has not been studied extensively and remains unclear.
|
30867652 |
2019 |
|
Caudal Regression Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
This case raises the question as to whether hyperglycaemia in GCK-MODY may increase the risk of fetal caudal regression syndrome as reported in women with pre-existing diabetes mellitus.
|
30362177 |
2019 |
|
Tracheobronchomalacia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Development of a persistent TCF was associated with younger age at placement, longer duration of tracheostomy, and the presence of tracheobronchomalacia.
|
31299421 |
2019 |
|
Hyperactive behavior
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
A similar relative hyper-enrichment was seen at the hnf4a loci of irradiated Atlantic salmon (Salmo salar) embryos (30 mGy/h for 10 days).
|
30759148 |
2019 |
|
Familial multiple trichoepitheliomata
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, these data provide a new way to categorize EAC at a genome scale and implicate HNF4A activation as a potential pivotal event in its malignant transition from healthy cells.
|
30962179 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IHC was utilized to assess the correlation between HNF4α and human equilibrative nucleoside transporter 1 (hENT1) expression in PDAC patients.
|
30867652 |
2019 |
|
Fanconi-Bickel Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mutations in the genes encoding the pancreatic K<sub>ATP</sub> channels can also lead to different types of diabetes (including neonatal diabetes mellitus (NDM) and Maturity Onset Diabetes of the Young, MODY), and defects in the solute carrier family 2 member 2 (<i>SLC2A2</i>) leads to diabetes mellitus as part of the Fanconi-Bickel syndrome.
|
31137773 |
2019 |
|
Idiopathic non-cirrhotic portal hypertension
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, HNF4α loss in adult hepatocytes could induce abnormal portal structures resembling the human idiopathic non-cirrhotic portal hypertension syndrome, which may result from endothelial- and epithelial-to-mesenchymal transitions.
|
30721564 |
2019 |
|
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Specifically, some key regulators from the miR-449 and miR-34b/c cluster, miR-200 family, miR-106a-363 cluster, miR-182/183, FOX family, GATA family, and E2F family as well as CEBPA, SOX9 and HNF4A were suggested to play vital regulatory roles in the pathogenesis of endometriosis.
|
29357938 |
2018 |