HOXA7, homeobox A7, 3204

N. diseases: 43; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.060 Biomarker group BEFREE Taken together, these results demonstrated the tumor suppressive role of miR-144-3p in NB and may advance the understanding of the underlying mechanisms of miR-144-3p and HOXA7 in NB. 30720179 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.060 Biomarker group BEFREE Silencing of HOTAIR and HOXA7 could effectively inhibit tumor growth and increase chemosensitivity of ovarian tumors in nude mice. 29455183 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.060 AlteredExpression group BEFREE HOXA7 expression in OSCC is markedly increased at both the mRNA and protein levels, and this is positively correlated with clinical stage and the degree of tumor differentiation. 28529281 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.060 AlteredExpression group BEFREE Analysis of HOXA7 and GATA2 expression in a bank of human primary tumors confirms that the expression of these genes is also reduced in human breast cancer. 21373886 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.060 Biomarker group BEFREE HOXA7 staining of tumor cell nuclei is correlated significantly with improved disease-specific survival (P = .0104), which is suggestive of the biological and potentially clinical importance of subcellular HOXA7 localization. 17959889 2007
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.060 PosttranslationalModification group BEFREE Methylation analysis of HOXA genes in primary squamous cell carcinomas of the lung led to the identification of the HOXA7- and HOXA9-associated CpG islands as frequent methylation targets in stage 1 tumors. 17369352 2007
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.030 Biomarker disease BEFREE Silencing of HOTAIR and HOXA7 could effectively inhibit tumor growth and increase chemosensitivity of ovarian tumors in nude mice. 29455183 2018
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.030 Biomarker disease BEFREE The study suggested that HOXA7 might be a new gene candidate that influences the maturation of acute myeloid leukemia, and provided the molecular basis for the treatment for acute promyelocyticleukemia. 26828989 2016
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.030 AlteredExpression disease BEFREE Interrelationships between HOXA7 expression and ovarian cancer progression are investigated by cDNA array and by immunohistochemistry of normal ovaries and 538 epithelial ovarian tumor microarrays. 17959889 2007
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.030 Biomarker disease BEFREE Coexpression of the homeodomain protein Meis1 and either HoxA7 or HoxA9 is characteristic of many acute myelogenous leukemias. 15479723 2005
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.030 Biomarker disease BEFREE These findings associate aberrant HOXA7 expression with the müllerian-like differentiation of epithelial ovarian tumors and suggest diagnostic utility of serum antibodies to HOXA7. 11742062 2001
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute
0.030 Biomarker disease BEFREE MEIS1 and HOXA7 genes in human acute myeloid leukemia. 10996203 2000
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.020 AlteredExpression disease BEFREE The effect of lncRNA HOTAIR on chemoresistance of ovarian cancer through regulation of HOXA7. 29455183 2018
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial
0.020 AlteredExpression disease BEFREE The effect of lncRNA HOTAIR on chemoresistance of ovarian cancer through regulation of HOXA7. 29455183 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.020 AlteredExpression disease BEFREE The expression and significance of the HOXA7 gene in oral squamous cell carcinoma. 28529281 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.020 AlteredExpression phenotype BEFREE Higher HOXA7 expression was also associated with the presence of vascular and nerve invasion, and lymph node and distant metastasis. 28529281 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.020 AlteredExpression phenotype BEFREE Higher HOXA7 expression was also associated with the presence of vascular and nerve invasion, and lymph node and distant metastasis. 28529281 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.020 Biomarker phenotype BEFREE In this report, we revealed that HOXA7 promoted metastasis of HCC patients. 27600149 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion
0.020 Biomarker phenotype BEFREE Moreover, HOXA7-siRNA inhibited migration and invasion in vitro, and downregulated MMP9 at the protein level in U251 glioma cells. 27677590 2016
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.020 Biomarker disease BEFREE Our results demonstrate a novel mechanistic role for HOXA7 in modulating breast cancer cell proliferation via regulation of ERα expression. 24099775 2013
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.020 Biomarker disease BEFREE Our results demonstrate a novel mechanistic role for HOXA7 in modulating breast cancer cell proliferation via regulation of ERα expression. 24099775 2013
CUI: C3888194
Disease: MIXED LINEAGE LEUKEMIA
MIXED LINEAGE LEUKEMIA
0.020 AlteredExpression disease BEFREE We also found that exogenous expression of miR-142-3p strongly reduced the expression of MLL-AF4 target genes such as homeobox A (HOXA)9, HOXA7, and HOXA10 in RS4;11 cells. 24057258 2013
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.020 AlteredExpression disease BEFREE Analysis of HOXA7 and GATA2 expression in a bank of human primary tumors confirms that the expression of these genes is also reduced in human breast cancer. 21373886 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.020 AlteredExpression disease BEFREE Analysis of HOXA7 and GATA2 expression in a bank of human primary tumors confirms that the expression of these genes is also reduced in human breast cancer. 21373886 2011
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma
0.020 AlteredExpression disease BEFREE Methylation analysis of HOXA genes in primary squamous cell carcinomas of the lung led to the identification of the HOXA7- and HOXA9-associated CpG islands as frequent methylation targets in stage 1 tumors. 17369352 2007