Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer.
|
11396184 |
2001 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that APC polymorphisms might be associated with CRC in the Chinese Han population.
|
22796397 |
2012 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Familial adenomatous polyposis (FAP), caused by a mutation in the APC gene, is a colorectal cancer predisposition syndrome associated with several other clinical conditions.
|
12721244 |
2003 |
Colorectal Carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The APC promoter is hypermethylated in 18% of primary sporadic colorectal carcinomas (n = 108) and adenoma (n = 48), and neoplasia with APC methylation fails to express the APC transcript.
|
10969779 |
2000 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We also tested whether other significant genetic or clinical status involved in CRC development, such as APC and TP53 mutations, MSI and TNM-Duke's staging, were related with the observed BRAF- or K-ras associated expression profiles.
|
16219636 |
2006 |
Colorectal Carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
MYC gene overexpression was identified recently as a downstream step at the end of the Wnt/APC/beta-catenin pathway dysregulation observed in colorectal cancer (T-C.
|
10383126 |
1999 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
By this method, we have been able to detect somatic mutations of the APC gene in 57% of colorectal cancers and none in non-small cell lung cancers.
|
10854222 |
2000 |
Colorectal Carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Restoration of APC gene function in colorectal cancer cells by aminoglycoside- and macrolide-induced read-through of premature termination codons.
|
19951906 |
2010 |
Colorectal Carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Molecular changes in the Ki-ras and APC genes in primary colorectal carcinoma and synchronous metastases compared with the findings in accompanying adenomas.
|
12782759 |
2003 |
Colorectal Carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the inactivation of the APC gene is very common in sporadic colorectal cancer, and the main inactivation mechanism of the APC gene is promoter hypermethylation.
|
18369740 |
2008 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
An APC gene sequence alteration, the I1307K allele, occurs in 6% of the Ashkenazi Jewish population and is reported to double the risk for colorectal cancer.
|
9679945 |
1998 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
To uncover novel causative genes in patients with unexplained adenomatous polyposis, a model disease for colorectal cancer, we performed a genome-wide analysis of germline copy number variants (CNV) in a large, well characterized APC and MUTYH mutation negative patient cohort followed by a targeted next generation sequencing (NGS) approach.
|
25219767 |
2015 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Four hundred two patients (89.3%) had MMR-proficient tumors, and 32 patients (8%) had at least 1 gene mutation: 9 had mutations in high-penetrance CRC genes (5, APC; 1, APC/PMS2; 2, biallelic MUTYH; 1, SMAD4); 13 patients had mutations in high- or moderate-penetrance genes not traditionally associated with CRC (3, ATM; 1, ATM/CHEK2; 2, BRCA1; 4, BRCA2; 1, CDKN2A; 2, PALB2); 10 patients had mutations in low-penetrance CRC genes (3, APC c.3920T>A, p.I1307K; 7, monoallelic MUTYH).
|
27978560 |
2017 |
Colorectal Carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf.
|
19378335 |
2009 |
Colorectal Carcinoma
|
0.800 |
PosttranslationalModification
|
disease |
BEFREE |
To study how caretaker gene silencing relates to gatekeeper mutations in colorectal cancer (CRC), we investigated whether O6-methylguanine DNA methyltransferase (MGMT) and Human Mut-L Homologue 1 (MLH1) promoter hypermethylation are associated with APC, KRAS and BRAF mutations among 734 CRC patients.
|
19164452 |
2009 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We assayed promoter methylation of 11 genes including established CpG island methylator phenotype (CIMP) markers (MLH1, MINT1, MINT2, MINT31, p16 ( INK4a ), p14 ( ARF ), and CACNA1G) and four genes (COX2, DAPK, MGMT, and APC) frequently methylated in colorectal cancer in 285 patients with sporadic colorectal cancer.
|
20077021 |
2010 |
Colorectal Carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
In the current study we evaluated the effect of X-ray irradiation on methylation levels of p16, MGMT and APC genes in colorectal cancers and normal colonic mucosa.
|
20885350 |
2010 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We conclude that mutations in exons 1 to 6 of the APC gene are infrequent in patients with familial colorectal cancer who do not have many colorectal polyps.
|
8835324 |
1995 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Prevalence of the APC E1317Q variant in colorectal cancer patients.
|
10737725 |
2000 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that germline variants in these genes may influence CRC risk, similar to APC, which is causing CRC through germline and somatic mutations.
|
24706189 |
2014 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The follow-up of these patients will show the likelihood of mutant APC progressing to CRC in CD.
|
19543899 |
2009 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The mutated in colorectal cancer (MCC) gene is in close linkage with the adenomatous polyposis coli (APC) gene on chromosome 5, in a region of frequent loss of heterozygosity in colorectal cancer.
|
17260021 |
2007 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We also identified apoptosis-related genes enriched with ancestor mutations in lung cancers and a relationship between APC hotspot mutations and TP53 mutations in colorectal cancers.
|
29697365 |
2018 |
Colorectal Carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The wnt/APC/<i>β</i>-catenin pathway is a critical initiator in colorectal carcinogenesis in both hereditary and sporadic colorectal cancer (CRC).
|
30186819 |
2018 |
Colorectal Carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
IMPLICATIONS: The tumor-suppressive function of APC, the most frequently mutated gene in colorectal cancer, is mainly attributed to its role in β-catenin/Wnt signaling.
|
31160382 |
2019 |