Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we report the disruption of the APC gene caused by somatic insertion of a long interspersed repetitive element (LINE-1 sequence) into the last exon of the APC gene in a colon cancer.
|
1310068 |
1992 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
High-resolution banding studies indicated that the deletion in the patient with polyposis spans the region 5q21-q22, which includes APC, a gene involved in familial adenomatous polyposis and sporadic colon cancer.
|
1315124 |
1992 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
They imply that inactivation of APC, MCC, and/or a linked gene on chromosome 5q plays a role in the pathogenesis of some cancers of the upper gastrointestinal tract, as well as in colon cancer and familial adenomatous polyposis.
|
1565631 |
1992 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The APC gene, mutations in which are responsible for the inherited colon cancer syndrome adenomatous polyposis coli (APC), is described as a tumor suppressor gene.
|
7882361 |
1995 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The APC gene on chromosome 5 causing adenomatous polyposis coli represents a minority of the inherited colon cancer cases, while hereditary-non polyposis colon cancer (HNPCC) may cause five percent of all human colon cancer.
|
7903889 |
1993 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The APC gene is a putative human tumor-suppressor gene responsible for adenomatous polyposis coli (APC), an inherited, autosomal dominant predisposition to colon cancer.
|
8381581 |
1993 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A database is described in which over 700 mutations in the human APC gene of tumors (colon cancer predominantly) are compiled from the literature.
|
8594558 |
1996 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In summary, we did not detect any functional mutations of the APC gene in a wide variety of tumors except for a colon cancer cell line, suggesting that alterations of the APC gene do not have a major role in the development of lung and renal cancers, various types of sarcomas, or hematological malignancies.
|
9083931 |
1997 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The APC/MCC gene (Familial Adenomatous Polyposis) at 5q21 plays a role in colon cancer carcinogenesis.
|
9182290 |
1996 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Colon cancer. Molecular biology of the APC protein.
|
9296069 |
1997 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, this model may have some relevance and application to the study of colon cancer in human inflammatory bowel disease, which is not associated with APC mutations or with Ki-ras or p53 mutations.
|
9433483 |
1997 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Peptide-mediated precipitation experiments showed that anti-APCp1 bound and sequestered wild-type and mutant APC proteins in extracts of human colon cancer cell lines.
|
9663391 |
1998 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Loss of heterozygosity of APC and DCC tumor suppressor genes in human sporadic colon cancer.
|
10090594 |
1999 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have shown that the family's phenotype does not result from APC mutations (including the I1307K variant) or from genetic changes in the other known genes that predispose to colon cancer.
|
10092300 |
1999 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Defects in the APC-beta-catenin pathway are common in colon cancer.
|
10507776 |
1999 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The reported association between the APC I1307K mutation and colon cancer risk was supported by a correlation in these data between personal or family history of CRC or polyps and a gene mutation.
|
10756345 |
2000 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The adenomatous polyposis coli (APC) gene was first identified as the gene mutated in an inherited syndrome of colon cancer predisposition known as familial adenomatous polyposis coli (FAP).
|
10784639 |
2000 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest APC mutations alter regulation of both beta- and gamma-catenin, perhaps explaining why the frequency of APC mutations in colon cancer far exceeds that of beta-catenin mutations.
|
10837025 |
2000 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine whether this D1822V [corrected] variant of the APC gene is associated with colon cancer and whether its association is influenced by other genetic or environmental factors.
|
11221825 |
2001 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inactivation of the tumor suppressor adenomatous polyposis coli (APC) protein is a critical early step in the development of familial and sporadic colon cancer.
|
11237529 |
2001 |
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study concluded that rectal cancer may involve more nuclear beta-catenin in the APC/beta-catenin pathway than colon cancer and/or nuclear beta-catenin may have another role in rectal cancer independently of APC.
|
11592095 |
2001 |
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer.
|
11751382 |
2001 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The apparently low incidence of colon cancer in the African population may be ascribed either to the rare occurrence of the 'second hit' needed for polyp formation or to a lower incidence of mutations in the APC gene.
|
12000364 |
2002 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have found a significant concordance between the in vitro replication errors of human DNA polymerase beta and in vivo point mutations of the adenomatous polyposis coli (APC) gene that leads to colon cancer.
|
12036944 |
2002 |
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The tumor did not show somatic mutation of the APC and K-ras genes, which is a critical step for the adenoma-carcinoma sequence in colon cancer.
|
12051537 |
2002 |