Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
To understand and dissect the mechanisms driving human NK cell proliferation, we exploited the methodology used in cell therapy to numerically expand NK cells in the presence of K562-derived artificial APC (aAPCs) and cytokines.
|
31201235 |
2019 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
The adenomatous polyposis coli (APC) gene plays, among other things, a crucial role in the regulation of cell proliferation and survival through its ability to regulate canonical Wnt signaling.In this issue of the JCI, Wang et al. provide an intriguing new mechanism for APC function involving the regulation of a novel long noncoding RNA (lncRNA), leading to changes in exosome production.
|
30640173 |
2019 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While not all APC mutant peptides are inmmunogenic, a few qualify as vaccine candidates offering novel treatment opportunities to patients with somatic APC gene mutations to delay/treat colorectal cancer.
|
30256815 |
2018 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four (14%) were found to have APC pathogenic truncations of the APC protein and in addition two (7%) had APC missense variants of unknown clinical significance.
|
29251405 |
2018 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Resistance to APC (APCR) is a very important cause of thrombophilia and most frequently caused by the Leiden mutation.
|
28063132 |
2017 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
CtBP interacts with adenomatous polyposis coli (APC) protein, and is stabilized in both APC-mutated human colon cancers and Apc<sup>min/+</sup> intestinal polyps.
|
28414304 |
2017 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APC gene mutations have been associated to have a role in colon cancer and since gastric and colon tumors share some common genetic lesions, it is relevant to investigate the role of APC tumor suppressor gene in gastric cancer.
|
28576136 |
2017 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Chinese and English literature on APC germline mutations were reviewed to compile the mutation spectrum of APC gene in Chinese FAP patients.
|
26625971 |
2016 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
FAP is associated with germline defects of APC tumor suppressor gene; although truncating mutations account for the majority of cases, large APC deletions represent a common disease-causing defect.
|
25159889 |
2015 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since the Adenomatous Polyposis Coli (APC) gene is mutated in the majority of human colon cancers and often occurs simultaneously with PIK3CA mutations, we sought to better understand the interaction between APC and PIK3CA mutations in the mammalian intestine.
|
23708654 |
2014 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The study investigated the relationship between clinicopathological characteristics, Helicobacter pylori (Hp) infection, adenomatous polyposis coli (APC) promoter methylation, APC and β-catenin immunohistochemistry expression and mutation status, compared with 38 gastric adenoma and periadenomatous tissues (PTs).
|
22741528 |
2012 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The cellular polarity of intestinal tumor cells was examined using APC(Min/+) mice as an in vivo model and SW480 cells with a truncating mutation in the adenomatous polyposis coli (APC) gene as an in vitro model by confocal microscopy.
|
21484796 |
2012 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic testing revealed a mutation in the 5' portion of the adenomatous polyposis coli (APC) gene, in a region associated with an attenuated APC phenotype.
|
22150579 |
2012 |
Atrial Premature Complexes
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The abnormal expression of APC suggests that APC gene may play a role in cutaneous SCC development.
|
21518821 |
2011 |
Atrial Premature Complexes
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, we have cloned the cDNA of the APC tumour suppressor gene into a replication competent Herpesvirus saimiri (HVS)-based vector to assess APC gene delivery in SW480 and SW620 CRC cell lines.
|
21769429 |
2011 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
APC(min/+) mice, carrying a nonsense mutation in the adenomatous polyposis coli (APC) gene, appear as a perfect model to study development or therapy of intestinal neoplasia.
|
21649465 |
2011 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using the adenomatous polyposis coli (APC) gene as an example, we identified 210 highly reliable SNPs by next-generation sequencing analysis program MAQ and Samtools, of which 69 were novel ones, in the 123-kb APC genomic region in 27 pair of colorectal cancers and normal adjacent tissues.
|
20569184 |
2010 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While germline mutations in the adenomatous polyposis coli (APC) gene cause the hereditary colon cancer syndrome (familial adenomatous polyposis (FAP)), the role of common germline APC variants in sporadic adenomatous polyposis remains unclear.
|
20510605 |
2010 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have added the APC germline-mutation data for Taiwanese FAP patients and indicated the presence of an FAP subgroup comprising affected individuals with nonadenomatous polyps or less than 100 adenomatous polyps; this form of FAP is less frequently caused by germline mutations of the APC gene.
|
19768578 |
2010 |
Atrial Premature Complexes
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Assessment of APC promoter methylation revealed that normal tissues were unmethylated, while twenty out of forty five (44.4%) tumor tissues were hypermethylated either in one or both alleles of APC.
|
19149902 |
2009 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study we set out to test the hypothesis that loss of Rassf1a can cooperate with inactivation of the adenomatous polyposis coli (Apc) gene to accelerate intestinal tumourigenesis using the Apc-Min (Apc(Min/+)) mouse model, as mutational or deletional inactivation of APC is a frequent early event in the genesis of intestinal cancer.
|
18391979 |
2008 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Because dynactin, a dynein regulator, interacts with end-binding protein 1 (EB1) and beta-catenin, two known binding partners of the adenomatous polyposis coli (APC) protein, we looked for a genetic interaction between Lis1 and APC.
|
18075263 |
2008 |
Atrial Premature Complexes
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In our study, we used bisulfite treatment and direct sequencing of 2 regulatory regions of APC containing a total of 25 CpG dinucleotides, to investigate the possible role of germline hypermethylation of the APC promoter in FAP and AFAP families that were negative for APC and MUTYH mutations.
|
18027849 |
2008 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Four missense APC gene alterations (S130G, E1317Q, D1822V, G2502S) were observed in 13 individuals and 3 additional patients carried presumed pathogenic (APC Y94X, biallelic MYH Y165C and heterozygous MYH G382D) mutations.
|
18612690 |
2008 |
Atrial Premature Complexes
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Most APC gene mutations cause deletion of the C terminus and disrupt APC regulation of beta-catenin turnover, microtubule dynamics, and chromosome segregation.
|
18160396 |
2008 |