HP, haptoglobin, 3240

N. diseases: 464; N. variants: 9
Disease: Sickle Cell Trait ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0037054
Disease: Sickle Cell Trait
Sickle Cell Trait 		0.030 GeneticVariation disease BEFREE The objective was to investigate whether haptoglobin (Hp) haplotypes constructed from the functional polymorphism (Hp1/Hp2) plus the functional promoter SNPs -61A-C (rs5471) and -101C-G (rs5470), or sickle cell trait (HbAS, rs334) were associated with risk of active trachoma when stratified by age and sex, in rural Gambian children. 20552021 2010
CUI: C0037054
Disease: Sickle Cell Trait
Sickle Cell Trait 		0.030 AlteredExpression disease BEFREE Decreased Hp expression may lead to increased oxidant stress and increased red cell turnover, and facilitate the development of acquired immunity, similar to a mechanism suggested for sickle cell trait. 17426810 2007
CUI: C0037054
Disease: Sickle Cell Trait
Sickle Cell Trait 		0.030 AlteredExpression disease BEFREE Sickle cell trait and ABO blood group was not associated with Hp levels in this population. 16407342 2006