HPR, haptoglobin-related protein, 3250

N. diseases: 94; N. variants: 5
Disease: Zika Virus Infection ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection 		0.030 Biomarker disease BEFREE Three drugs (Act-D, cyclosporin A, ivermectin) exhibited a strong adulticidal activity, and six drugs (U18666A, retinoic acid p-hydroxyanilide (4-HPR), clotrimazole, bortezomib, MPA, imatinib mesylate) significantly suppressed ZIKV infection in mosquito midguts. 31430351 2019
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection 		0.030 Biomarker disease BEFREE Since 4-HPR can also inhibit DENV-related flaviviruses of medical significance such as West Nile Virus and Zika virus, it is of great interest for future commercialisation. 29845535 2018
CUI: C0276289
Disease: Zika Virus Infection
Zika Virus Infection 		0.030 Biomarker disease BEFREE These results establish 4-HPR's mode of action against DV and ZIKV and, taken with previous clinical trials that established 4-HPR's safety and tolerability, illustrate the potential utility of 4-HPR as an agent for treatment of ZIKV infection. 29051080 2017