HPR, haptoglobin-related protein, 3250

N. diseases: 94; N. variants: 5
Disease: Neuroblastoma recurrent ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278695
Disease: Neuroblastoma recurrent
Neuroblastoma recurrent 		0.020 AlteredExpression disease BEFREE Fenretinide (4-HPR) is a cytotoxic retinoid with clinical activity in recurrent neuroblastoma and venetoclax (ABT-199) is a selective inhibitor of the antiapoptotic protein B-cell lymphoma-2 (BCL-2). 31484706 2019
CUI: C0278695
Disease: Neuroblastoma recurrent
Neuroblastoma recurrent 		0.020 AlteredExpression disease BEFREE The LXS oral powder 4-HPR formulation increased plasma levels approximately two-fold at MTD in children without dose-limiting toxicities and demonstrated multiple complete responses in recurrent neuroblastoma. 28429653 2017