AIRE, autoimmune regulator, 326

N. diseases: 175; N. variants: 85
Disease: Uveitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042164
Disease: Uveitis
Uveitis 		0.020 GeneticVariation disease BEFREE The spontaneous models of uveitis in R161H and AIRE(-/-) mice have a gradual onset and develop chronic ocular inflammation that ultimately leads to retinal degeneration, along with a progressive decline of visual signal. 26238369 2015
CUI: C0042164
Disease: Uveitis
Uveitis 		0.020 GeneticVariation disease BEFREE We compared three mouse models of uveitis that target the interphotoreceptor retinoid binding protein (IRBP): (i) the "classical" model of experimental autoimmune uveitis (EAU) induced by immunization with IRBP; (ii) spontaneous uveitis in IRBP T cell receptor transgenic mice (R161H) and (iii) spontaneous uveitis in Autoimmune Regulator (AIRE)(-/-) mice. 24015215 2013