HRAS, HRas proto-oncogene, GTPase, 3265

N. diseases: 698; N. variants: 29
Disease: Pancreatitis, Chronic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.050 GeneticVariation disease BEFREE Histopathological features of patients with chronic pancreatitis due to mutations in the PRSS1 gene: evaluation of BRAF and KRAS2 mutations. 18946221 2008
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.050 GeneticVariation disease BEFREE Among patients with mutant KRAS2 positive cancers, all but one (94%) had mutant KRAS2 DNA concentrations of more than 0.5% in their pancreatic juice samples, whereas only 1 of 9(11%) pancreatic juice samples from patients with chronic pancreatitis had more than 0.5% mutant KRAS2 DNA, corresponding to a sensitivity of 94% and a specificity of 89%. 18075308 2008
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.050 GeneticVariation disease BEFREE KRAS2 mutations were found in 22 patients (47%) with pancreatic cancer and in four controls with chronic pancreatitis (13%) (P<0.002). 12189555 2002
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.050 GeneticVariation disease BEFREE At present, K-ras-2 mutation is not useful for differentiating pancreatic cancer from chronic pancreatitis or the identification of patients with chronic pancreatitis at risk for malignant transformation. 11677475 2001
CUI: C0149521
Disease: Pancreatitis, Chronic
Pancreatitis, Chronic 		0.050 Biomarker disease BEFREE The role of p21ras in pancreatic neoplasia and chronic pancreatitis. 10374765 1999