|
Trophoblastic Neoplasms
|
0.010 |
Biomarker
|
group |
LHGDN |
HSD3B1 immunoreactivity was detected in intermediate trophoblast and syncytiotrophoblast in 21 early placentas, 18 complete hydatidiform moles, 67 trophoblastic tumors, including placental site trophoblastic tumors, epithelioid trophoblastic tumors, and choriocarcinomas, and 28 tumorlike lesions including placental site nodules and exaggerated placental site.
|
18223326 |
2008 |
|
Trophoblastic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
HSD3B1 as a novel trophoblast-associated marker that assists in the differential diagnosis of trophoblastic tumors and tumorlike lesions.
|
18223326 |
2008 |
|
Exaggerated placental site
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSD3B1 immunoreactivity was detected in intermediate trophoblast and syncytiotrophoblast in 21 early placentas, 18 complete hydatidiform moles, 67 trophoblastic tumors, including placental site trophoblastic tumors, epithelioid trophoblastic tumors, and choriocarcinomas, and 28 tumorlike lesions including placental site nodules and exaggerated placental site.
|
18223326 |
2008 |
|
Polycystic Ovary Syndrome
|
0.520 |
Biomarker
|
disease |
RGD |
Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat.
|
19698287 |
2009 |
|
Malignant neoplasm of prostate
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To estimate the prostate cancer risk conferred by individual single nucleotide polymorphisms (SNPs), SNP-SNP interactions, and/or cumulative SNP effects, we evaluated the association between prostate cancer risk and the genetic variants of 12 key genes within the steroid hormone pathway (CYP17, HSD17B3, ESR1, SRD5A2, HSD3B1, HSD3B2, CYP19, CYP1A1, CYP1B1, CYP3A4, CYP27B1, and CYP24A1).
|
19505920 |
2009 |
|
Hypertensive disease
|
0.210 |
Biomarker
|
group |
RGD |
Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system.
|
19228890 |
2009 |
|
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To estimate the prostate cancer risk conferred by individual single nucleotide polymorphisms (SNPs), SNP-SNP interactions, and/or cumulative SNP effects, we evaluated the association between prostate cancer risk and the genetic variants of 12 key genes within the steroid hormone pathway (CYP17, HSD17B3, ESR1, SRD5A2, HSD3B1, HSD3B2, CYP19, CYP1A1, CYP1B1, CYP3A4, CYP27B1, and CYP24A1).
|
19505920 |
2009 |
|
Diabetes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The genetic polymorphisms of the ApoE, HSD3B1, IL-1beta and p53 genes were found to be significantly different (p<0.05) between the uremic and non-uremic diabetes group.
|
19148546 |
2009 |
|
Diabetes Mellitus
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The genetic polymorphisms of the ApoE, HSD3B1, IL-1beta and p53 genes were found to be significantly different (p<0.05) between the uremic and non-uremic diabetes group.
|
19148546 |
2009 |
|
Endometriosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In 8-Br-cAMP-treated hESF from eutopic endometrium of women with endometriosis, the balance in estradiol (E2) and P4 biosynthetic and metabolizing enzymes is disturbed (decreased HSD3B1 and HSD17B2, and increased HSD17B1 and aromatase), with the equilibrium being shifted towards an E2-enriched milieu.
|
18815356 |
2009 |
|
Malignant neoplasm of prostate
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that activation of AR in prostate cancer by DHEA and A5diol requires their conversion via 3betaHSD to androstenedione and testosterone, respectively.
|
20534728 |
2010 |
|
Prostate carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that activation of AR in prostate cancer by DHEA and A5diol requires their conversion via 3betaHSD to androstenedione and testosterone, respectively.
|
20534728 |
2010 |
|
Hormone refractory prostate cancer
|
0.060 |
Biomarker
|
disease |
BEFREE |
Furthermore, this work suggests that 3betaHSD may be exploited as a pharmacologic target in the treatment of CRPC.
|
20534728 |
2010 |
|
Essential Hypertension
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
rs6203 and rs1047303 in the HSD3B1 gene are useful genetic markers for EH, while polymorphisms of HSD3B1 are associated with the BP and aldosterone level.
|
20660004 |
2010 |
|
Left Ventricular Hypertrophy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We performed a haplotype- and diplotype-based case-control study to investigate the association between the HSD3B gene variations and essential hypertension (EH), aldosterone level, and left ventricular hypertrophy (LVH).
|
20660004 |
2010 |
|
Familial lichen amyloidosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We also investigated associations between SNPs in genes (HSD3B1, SRD5A1/2, and AKR1C2) involved in the conversion of testosterone to DHT, and in DHT metabolism and PCA risk.
|
20056642 |
2010 |
|
Severe myopia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
An MDR analysis corroborated the synergistic genotype association and demonstrated that synergistic interaction between rs6203 (HSD3B1), rs10046 (CYP19A1), and sex might confer susceptibility to high myopia (p=0.019).
|
21921981 |
2011 |
|
Polycystic Ovary Syndrome
|
0.520 |
Biomarker
|
disease |
CTD_human |
The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients.
|
22381227 |
2012 |
|
Sclerocystic Ovaries
|
0.300 |
Biomarker
|
disease |
CTD_human |
The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients.
|
22381227 |
2012 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer.
|
23284679 |
2012 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer.
|
23284679 |
2012 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
HSD3B and gene-gene interactions in a pathway-based analysis of genetic susceptibility to bladder cancer.
|
23284679 |
2012 |
|
Pregnancy associated hypertension
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The aim of this haplotype-based case-control study was to estimate whether polymorphisms of the maternal estrogen synthesis genes (CYP19A1, HSD3B1 and HSD3B2) are associated with preeclampsia (PE) and gestational hypertension (GH).
|
22638611 |
2012 |
|
Acne Vulgaris
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study shows that rs6428829 in HSD3B1 was associated with acne vulgaris in Han patients from Southwest China, even after adjusting for age and sex.
|
24157973 |
2013 |
|
Aortic Valve Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further analysis suggested that increased expression of HSD3B1 and reduced expression of androgen receptor (AR) promoted adaptation to androgen-abundant conditions, as indicated by the increased conversion of DHT into 3β-diol by HSD3B1 and AR signal reduction.
|
23780684 |
2013 |