|
Polycystic Ovary Syndrome
|
0.520 |
GeneticVariation
|
disease |
BEFREE |
Carrying the HSD3B1 1245C allele and overweight are associated with the presence of female pattern hair loss in women with polycystic ovary syndrome.
|
31056381 |
2019 |
|
Polycystic Ovary Syndrome
|
0.520 |
Biomarker
|
disease |
CTD_human |
The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients.
|
22381227 |
2012 |
|
Polycystic Ovary Syndrome
|
0.520 |
Biomarker
|
disease |
RGD |
Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat.
|
19698287 |
2009 |
|
Polycystic Ovary Syndrome
|
0.520 |
GeneticVariation
|
disease |
LHGDN |
The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency.
|
14764797 |
2004 |
|
Malignant neoplasm of prostate
|
0.400 |
Biomarker
|
disease |
BEFREE |
HSD3B1 Genotypes Conferring Adrenal-Restrictive and Adrenal-Permissive Phenotypes in Prostate Cancer and Beyond.
|
31271415 |
2019 |
|
Malignant neoplasm of prostate
|
0.400 |
Biomarker
|
disease |
BEFREE |
AR Signaling in Prostate Cancer Regulates a Feed-Forward Mechanism of Androgen Synthesis by Way of HSD3B1 Upregulation.
|
29850791 |
2018 |
|
Malignant neoplasm of prostate
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, the HSD3B1 (1245C) allele was associated with more rapid development of metastases in men treated with ADT for biochemical recurrence after primary radiation therapy for prostate cancer.
|
29049492 |
2018 |
|
Malignant neoplasm of prostate
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We hypothesized that the HSD3B1 (1245C) variant predicts response to treatment with abiraterone acetate (AA) and can help personalize treatment in men with advanced prostate cancer.
|
29674118 |
2018 |
|
Malignant neoplasm of prostate
|
0.400 |
Biomarker
|
disease |
BEFREE |
HSD3B1 status as a biomarker of androgen deprivation resistance and implications for prostate cancer.
|
29231195 |
2018 |
|
Malignant neoplasm of prostate
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
HSD3B1(1245A>C) variant regulates dueling abiraterone metabolite effects in prostate cancer.
|
29939161 |
2018 |
|
Malignant neoplasm of prostate
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Inheritance of the HSD3B1 (1245C) allele that enhances dihydrotestosterone synthesis is associated with prostate cancer resistance to ADT.
|
27575027 |
2016 |
|
Malignant neoplasm of prostate
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that activation of AR in prostate cancer by DHEA and A5diol requires their conversion via 3betaHSD to androstenedione and testosterone, respectively.
|
20534728 |
2010 |
|
Malignant neoplasm of prostate
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To estimate the prostate cancer risk conferred by individual single nucleotide polymorphisms (SNPs), SNP-SNP interactions, and/or cumulative SNP effects, we evaluated the association between prostate cancer risk and the genetic variants of 12 key genes within the steroid hormone pathway (CYP17, HSD17B3, ESR1, SRD5A2, HSD3B1, HSD3B2, CYP19, CYP1A1, CYP1B1, CYP3A4, CYP27B1, and CYP24A1).
|
19505920 |
2009 |
|
Malignant neoplasm of prostate
|
0.400 |
Biomarker
|
disease |
CTD_human |
These results suggest that the HSD3B1 N367T and UGT2B17 null polymorphisms may modify the risk of prostate cancer, particularly among men with a family history of the disease.
|
17826523 |
2007 |
|
Malignant neoplasm of prostate
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the HSD3B1 N367T and UGT2B17 null polymorphisms may modify the risk of prostate cancer, particularly among men with a family history of the disease.
|
17826523 |
2007 |
|
Malignant neoplasm of prostate
|
0.400 |
Biomarker
|
disease |
BEFREE |
To evaluate the possible role of HSD3B genes in prostate cancer, we screened a panel of DNA samples collected from 96 men with or without prostate cancer for sequence variants in the putative promoter region, exons, exon-intron junctions, and 3'-untranslated region of HSD3B1 and HSD3B2 genes by direct sequencing.
|
11912155 |
2002 |
|
Prostatic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk.
|
17826523 |
2007 |
|
Prostatic Neoplasms
|
0.310 |
GeneticVariation
|
group |
LHGDN |
Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk.
|
17826523 |
2007 |
|
Sclerocystic Ovaries
|
0.300 |
Biomarker
|
disease |
CTD_human |
The expression of sex steroid synthesis and inactivation enzymes in subcutaneous adipose tissue of PCOS patients.
|
22381227 |
2012 |
|
Hypertensive disease
|
0.210 |
GeneticVariation
|
group |
BEFREE |
We found no evidence to support confirmation that HSD3B1 is involved in aldosterone synthesis in the human adrenal cortex or that genetic variation in HSD3B1 affects blood pressure or hypertension, favoring the hypothesis that all adrenocortical steroidogenesis is primarily dependent on the type II 3β-hydroxysteroid dehydrogenase.
|
24951726 |
2015 |
|
Hypertensive disease
|
0.210 |
Biomarker
|
group |
RGD |
Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system.
|
19228890 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.200 |
Biomarker
|
disease |
RGD |
[Ginkgo biloba extract enhances testosterone synthesis of Leydig cells in type 2 diabetic rats].
|
18481435 |
2008 |
|
Hypogonadism
|
0.200 |
Biomarker
|
disease |
RGD |
Strontium fructose 1,6-diphosphate rescues adenine-induced male hypogonadism and upregulates the testicular endothelin-1 system.
|
17880366 |
2007 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
RGD |
Hypothyroidism prolongs corpus luteum function in the pregnant rat.
|
17244746 |
2007 |
|
Sciatic Neuropathy
|
0.200 |
Biomarker
|
disease |
RGD |
Increased expression of 3 beta-hydroxysteroid dehydrogenase mRNA in dorsal root ganglion neurons of adult rats following peripheral nerve injury.
|
12648755 |
2003 |