|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Our data suggest that HSD11B2 is associated with hypertension in our black subjects with hypertensive end-stage renal disease.
|
8794836 |
1996 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The syndrome of AME is a rare form of juvenile hypertension in which 11-HSD is defective.
|
9034789 |
1997 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Statistical analyses using the affected sib-pair method did not show significant linkage between the 11beta-HSD2 microsatellite marker and hypertension.
|
9856363 |
1998 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The enhanced cortisol levels are backed by recent genetic findings on HSD11B2 polymorphisms and may promote hypertension.
|
18337758 |
2008 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Impaired 11beta-HSD2 activity has been suggested in patients with hypertension as well as in patients with renal disease, where it may contribute to sodium retention, oedema and hypertension.
|
16061836 |
2005 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The aim of the study was to analyze the HSD11B2 gene to assess whether some of its variants might be involved in hypertension.
|
16109323 |
2005 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
AME represents a spectrum of mineralocorticoid hypertension with severity reflecting the underlying genetic defect in the 11beta-HSD2 gene; classification into distinct subtypes is inappropriate.
|
9683587 |
1998 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Because polymorphisms in HSD11B2 have been associated with hypertension and salt sensitivity, we characterized the human VPATPD gene.It spans 19 kb and consists of 8 exons.
|
11118322 |
2000 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
We have investigated the role of HSD11B2 in hypertension in 377 genetically homogeneous essential hypertensives from North Sardinia.
|
15673310 |
2005 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
The isozyme 11beta-HSD2 is selectively expressed in mineralocorticoid target tissues and its activity is reduced in various disease states with abnormal sodium retention and hypertension, including the apparent mineralocorticoid excess.
|
25133511 |
2014 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Because hypertension in Black people tends to be of the low-renin, salt sensitive type, we genotyped independent sets of hypertensives of Afro-American (59 kindreds) and Afro-Caribbean (66 kindreds) origin using a highly polymorphic (heterozygosity index 0.84) CA repeat polymorphism in the first intron of HSD11B2.
|
11531933 |
2001 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
These findings indicate that variants of the HSD11B2 gene may contribute to the enhanced blood pressure response to salt and possibly to hypertension in humans.
|
19909806 |
2010 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Our data suggest that kidney-specific deficiency of 11β-HSD2 leads to salt-dependent hypertension, which is attributed to mineralocorticoid receptor-epithelial sodium channel-Na<sup>+</sup>-Cl<sup>-</sup> cotransporter activation in the kidney, and provides evidence that renal dysfunction is essential for developing the phenotype of apparent mineralocorticoid excess.
|
28559392 |
2017 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
AME represents a spectrum of mineralocorticoid hypertension with severity reflecting the underlying genetic defect in the 11beta-HSD2; although AME is a genetic disorder, several exogenous compounds can bring about the symptoms by inhibiting 11beta-HSD2 enzyme.
|
15761540 |
2004 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
To gain insight into potentially relevant miRNAs in vivo, we investigated 2 models with differential 11β-HSD2 activity linked with salt-sensitive hypertension.
|
24980668 |
2014 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Because the hypertension associated with AME is of the salt-sensitive type, it seemed possible that decreases in 11-HSD2 activity might be associated with salt sensitivity.
|
10948076 |
2000 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
The deactivation of glucocorticoid by 11βHSD2 controls ligand access to glucocorticoid and mineralocorticoid receptors: loss of function promotes salt retention and hypertension.
|
29138984 |
2017 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The syndrome of apparent mineralocorticoid excess (AME) is an inherited form of hypertension in which 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) is defective.
|
8979285 |
1997 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
The current study was conducted to determine if reduced 11β-HSD2 activity is also associated with having resistant HTN.
|
28180242 |
2017 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Genotyping indicated no hypertension related mutations in the coding region and short introns of HSD11B2.
|
23303402 |
2013 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Furthermore, polymorphisms in the 11β-HSD2 coding gene (HSD11B2) have been linked to high blood pressure and salt sensitivity, major cardiovascular risk factors.
|
28938454 |
2017 |
|
Hypertensive disease
|
0.700 |
PosttranslationalModification
|
group |
BEFREE |
These results show a clear link between the epigenetic regulation through repression of HSD11B2 in PBMC DNA and hypertension.
|
18178212 |
2008 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
A genetic association of a microsatellite flanking the HSD11B2 gene and hypertension in black patients with end-stage renal disease has been reported.
|
10760070 |
2000 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Serum F/E ratio and cortisone allow to identify partial 11βHSD2 deficiencies, as occurs in heterozygous subjects, who would be susceptible to develop arterial hypertension.
|
29617893 |
2018 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Variable activity of 11 beta HSD2 is relevant for blood pressure control and hypertension.
|
15489962 |
2004 |