|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Because hypertension in Black people tends to be of the low-renin, salt sensitive type, we genotyped independent sets of hypertensives of Afro-American (59 kindreds) and Afro-Caribbean (66 kindreds) origin using a highly polymorphic (heterozygosity index 0.84) CA repeat polymorphism in the first intron of HSD11B2.
|
11531933 |
2001 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
A microsatellite marker within the HSD11B2 gene associates with salt sensitivity and hypertension--phenotypes characterising diabetic nephropathy.
|
11916625 |
2002 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
LHGDN |
The decreased activity of 11beta-HSD2 increases the intracellular availability of cortisol, which might be relevant for the pathogenesis of hypertension and preeclampsia.
|
12911547 |
2003 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
11beta-HSD2 protects the mineralocorticoid receptor from cortisol excess; mutations in the HSD11B2 gene explain an inherited form of hypertension, the syndrome of 'apparent mineralocorticoid excess', in which 'Cushing's disease of the kidney' results in cortisol-mediated mineralocorticoid excess.
|
12943516 |
2003 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Variable activity of 11 beta HSD2 is relevant for blood pressure control and hypertension.
|
15489962 |
2004 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Mutations in the gene encoding 11beta-HSD2 (HSD11B2) account for an inherited form of hypertension, the syndrome of "Apparent Mineralocorticoid Excess" (AME) where cortisol induces hypertension and hypokalaemia.
|
15134813 |
2004 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Impaired 11-beta hydroxysteroid dehydrogenase type 2 activity in sweat gland ducts in human essential hypertension.
|
14981055 |
2004 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
AME represents a spectrum of mineralocorticoid hypertension with severity reflecting the underlying genetic defect in the 11beta-HSD2; although AME is a genetic disorder, several exogenous compounds can bring about the symptoms by inhibiting 11beta-HSD2 enzyme.
|
15761540 |
2004 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Variable activity of 11 beta HSD2 is relevant for blood pressure control and hypertension.
|
15489962 |
2004 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Impaired 11beta-HSD2 activity has been suggested in patients with hypertension as well as in patients with renal disease, where it may contribute to sodium retention, oedema and hypertension.
|
16061836 |
2005 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The aim of the study was to analyze the HSD11B2 gene to assess whether some of its variants might be involved in hypertension.
|
16109323 |
2005 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
We have investigated the role of HSD11B2 in hypertension in 377 genetically homogeneous essential hypertensives from North Sardinia.
|
15673310 |
2005 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Epidemiological data suggests that polymorphic variability in the HSD11B2 gene determines salt sensitivity in the general population, which is a key predisposing factor to adult onset hypertension in some patients.
|
16980198 |
2006 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
LHGDN |
In AME, defective HSD11B2 enzyme activity results in overstimulation of the mineralocorticoid receptor (MR) by cortisol, causing sodium retention, hypokalemia, and salt-dependent hypertension.
|
16778331 |
2006 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Therefore, impaired 11beta-HSD2 protein stability rather than reduced gene expression or loss of catalytic activity seems to be responsible for the development of hypertension in some individuals with AME.
|
17314322 |
2007 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The enhanced cortisol levels are backed by recent genetic findings on HSD11B2 polymorphisms and may promote hypertension.
|
18337758 |
2008 |
|
Hypertensive disease
|
0.700 |
PosttranslationalModification
|
group |
LHGDN |
These results show a clear link between the epigenetic regulation through repression of HSD11B2 in PBMC DNA and hypertension.
|
18178212 |
2008 |
|
Hypertensive disease
|
0.700 |
PosttranslationalModification
|
group |
BEFREE |
These results show a clear link between the epigenetic regulation through repression of HSD11B2 in PBMC DNA and hypertension.
|
18178212 |
2008 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
In conclusion, 19-nor-P did not inhibit human 11beta-HSD2 and seems not to be involved in human hypertension.
|
19811365 |
2009 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
These findings indicate that variants of the HSD11B2 gene may contribute to the enhanced blood pressure response to salt and possibly to hypertension in humans.
|
19909806 |
2010 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
It has been reported that the G534A(Glu178/Glu) polymorphism in the HSD11B2 gene is associated with hypertension.
|
22278213 |
2012 |
|
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Genotyping indicated no hypertension related mutations in the coding region and short introns of HSD11B2.
|
23303402 |
2013 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
The isozyme 11beta-HSD2 is selectively expressed in mineralocorticoid target tissues and its activity is reduced in various disease states with abnormal sodium retention and hypertension, including the apparent mineralocorticoid excess.
|
25133511 |
2014 |
|
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
To gain insight into potentially relevant miRNAs in vivo, we investigated 2 models with differential 11β-HSD2 activity linked with salt-sensitive hypertension.
|
24980668 |
2014 |
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
The hypertension phenotype is also epigenetically modulated by HSD11B2 methylation in subjects heterozygous for the mutation.
|
26126204 |
2015 |