Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The aim of the study was to analyze the HSD11B2 gene to assess whether some of its variants might be involved in hypertension.
|
16109323 |
2005 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
We have investigated the role of HSD11B2 in hypertension in 377 genetically homogeneous essential hypertensives from North Sardinia.
|
15673310 |
2005 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Variable activity of 11 beta HSD2 is relevant for blood pressure control and hypertension.
|
15489962 |
2004 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Mutations in the gene encoding 11beta-HSD2 (HSD11B2) account for an inherited form of hypertension, the syndrome of "Apparent Mineralocorticoid Excess" (AME) where cortisol induces hypertension and hypokalaemia.
|
15134813 |
2004 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
LHGDN |
Impaired 11-beta hydroxysteroid dehydrogenase type 2 activity in sweat gland ducts in human essential hypertension.
|
14981055 |
2004 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
AME represents a spectrum of mineralocorticoid hypertension with severity reflecting the underlying genetic defect in the 11beta-HSD2; although AME is a genetic disorder, several exogenous compounds can bring about the symptoms by inhibiting 11beta-HSD2 enzyme.
|
15761540 |
2004 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Variable activity of 11 beta HSD2 is relevant for blood pressure control and hypertension.
|
15489962 |
2004 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
LHGDN |
The decreased activity of 11beta-HSD2 increases the intracellular availability of cortisol, which might be relevant for the pathogenesis of hypertension and preeclampsia.
|
12911547 |
2003 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
11beta-HSD2 protects the mineralocorticoid receptor from cortisol excess; mutations in the HSD11B2 gene explain an inherited form of hypertension, the syndrome of 'apparent mineralocorticoid excess', in which 'Cushing's disease of the kidney' results in cortisol-mediated mineralocorticoid excess.
|
12943516 |
2003 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
A microsatellite marker within the HSD11B2 gene associates with salt sensitivity and hypertension--phenotypes characterising diabetic nephropathy.
|
11916625 |
2002 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Because hypertension in Black people tends to be of the low-renin, salt sensitive type, we genotyped independent sets of hypertensives of Afro-American (59 kindreds) and Afro-Caribbean (66 kindreds) origin using a highly polymorphic (heterozygosity index 0.84) CA repeat polymorphism in the first intron of HSD11B2.
|
11531933 |
2001 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Mutations in the HSD11B2 gene encoding the kidney (11-HSD2) isozyme of 11beta-hydroxysteroid dehydrogenase cause the syndrome of apparent mineralocorticoid excess, a form of salt-sensitive hypertension.
|
11196453 |
2000 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Thus, depending on the degree of loss of enzyme activity, 11 beta HSD2 mutations can cause a spectrum of phenotypes ranging from severe, life-threatening hypertension in infancy to a milder form of the disease in adults.
|
10726708 |
2000 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Because polymorphisms in HSD11B2 have been associated with hypertension and salt sensitivity, we characterized the human VPATPD gene.It spans 19 kb and consists of 8 exons.
|
11118322 |
2000 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Because the hypertension associated with AME is of the salt-sensitive type, it seemed possible that decreases in 11-HSD2 activity might be associated with salt sensitivity.
|
10948076 |
2000 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
RGD |
In the development of diabetes-induced hypertension, the effect of spironolactone on mean systolic blood pressure may be associated with the mineralocorticoid effects of corticosterone on renal MR, as well as an alteration of renal 11beta-HSD2 activity and its mRNA expression in insulin-dependent diabetic rats.
|
10792625 |
2000 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
A genetic association of a microsatellite flanking the HSD11B2 gene and hypertension in black patients with end-stage renal disease has been reported.
|
10760070 |
2000 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
CTD_human |
Functional adrenocorticotropic hormone receptor in cultured human vascular endothelial cells : possible role in control of blood pressure.
|
11082157 |
2000 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
These results reveal that cholic acid is able to induce hypertension and provide evidence that cholic acid inhibits the transcription of both 11beta-HSD2 and CYP11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels and increased vasoconstrictor responses to norepinephrine.
|
10399886 |
1999 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
In congenital 11beta-HSD deficiency and after administration of 11beta-HSD inhibitors, suppression of 11beta-HSD2 activity in the kidney has been believed to cause renal mineralocorticoid excess, resulting in sodium retention and hypertension.
|
10334808 |
1999 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
CTD_human |
Recently, we have studied an unusual patient with mild low-renin hypertension and a homozygous mutation in the HSD11B2 gene.
|
9707624 |
1998 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Recently, we have studied an unusual patient with mild low-renin hypertension and a homozygous mutation in the HSD11B2 gene.
|
9707624 |
1998 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Statistical analyses using the affected sib-pair method did not show significant linkage between the 11beta-HSD2 microsatellite marker and hypertension.
|
9856363 |
1998 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
AME represents a spectrum of mineralocorticoid hypertension with severity reflecting the underlying genetic defect in the 11beta-HSD2 gene; classification into distinct subtypes is inappropriate.
|
9683587 |
1998 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
CTD_human |
11 beta-HSD2 activity is not decreased in glucocorticoid hypertension (Cushing's syndrome).
|
9683905 |
1998 |