Endometriosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a promising therapeutic target known to play a pivotal role in the progression of estrogen-dependent diseases such as breast cancer, and endometriosis.
|
30273695 |
2018 |
Endometriosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The development of a covalent inhibitor of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a promising approach for the treatment of hormone-dependent breast cancer and endometriosis.
|
29248731 |
2018 |
Endometriosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
STS and 17β-HSD1 are attractive targets for the treatment of estrogen-dependent diseases like endometriosis and breast cancer.
|
28406629 |
2017 |
Endometriosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, we did not find statistical association of HSD17B1 937 A>G polymorphism with all infertile women with endometriosis or infertile women with endometriosis in stages III and IV.
|
28405865 |
2017 |
Endometriosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggested that HSD17B1 rs605059 polymorphisms were not associated with the risks of endometrial cancer and endometriosis.
|
26261478 |
2015 |
Endometriosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Comparing the stages I/II and III/IV endometriosis with the control group for the CYP2C19 we observed p = 0.0133 and p = 0.0564, respectively, and for HSD17B1 the values for p = 0.4319 and p = 0.0667.
|
25403437 |
2015 |
Endometriosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In all but one of the patients, a high type 1 17β-HSD level is associated with the unbalanced metabolism of estrogens, leading to higher estrogen synthesis in endometriosis than in the endometrium inside the uterus.
|
24187399 |
2014 |
Endometriosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results thus suggest that in peritoneal endometriosis the beneficial effects of these progestins can be explained by lower HSD17B1 and higher HSD17B2 mRNA and protein levels, which lead to reduced local E2 biosynthesis.
|
22878119 |
2012 |
Endometriosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in ESR1, ESR2, and HSD17B1 genes could modify susceptibility to endometriosis and might influence the fertility status in endometriosis patients.
|
20586553 |
2011 |
Endometriosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
In 8-Br-cAMP-treated hESF from eutopic endometrium of women with endometriosis, the balance in estradiol (E2) and P4 biosynthetic and metabolizing enzymes is disturbed (decreased HSD3B1 and HSD17B2, and increased HSD17B1 and aromatase), with the equilibrium being shifted towards an E2-enriched milieu.
|
18815356 |
2009 |
Endometriosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In 8-Br-cAMP-treated hESF from eutopic endometrium of women with endometriosis, the balance in estradiol (E2) and P4 biosynthetic and metabolizing enzymes is disturbed (decreased HSD3B1 and HSD17B2, and increased HSD17B1 and aromatase), with the equilibrium being shifted towards an E2-enriched milieu.
|
18815356 |
2009 |
Endometriosis
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Expression analysis of the genes involved in estradiol and progesterone action in human ovarian endometriosis.
|
17454161 |
2007 |
Endometriosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Evidence for association between the Ser312Gly polymorphism in HSD17B1 and endometriosis was found in a Japanese population.
|
15640252 |
2005 |
Endometriosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although not able to demonstrate interaction models of SNPs, we provide evidence of HSD17 vlV A->C as a low penetrance genetic marker of endometriosis.
|
16260521 |
2005 |
Endometriosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Evidence for association between the Ser312Gly polymorphism in HSD17B1 and endometriosis was found in a Japanese population.
|
15640252 |
2005 |
Endometriosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Another abnormality in endometriosis--deficient 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) type 2 expression--impairs the inactivation of estradiol (E2) to estrone (E1).
|
10652502 |
2001 |
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
BEFREE |
Considering the pivotal role of 17β-HSDs in steroid hormone modulation and their substrate specificity, these proteins are promising therapeutic targets for diseases like breast cancer, endometriosis, osteoporosis, and prostate cancer.
|
21193039 |
2011 |
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
CTD_human |
Our results provide suggestive findings for an association with either familial or sporadic prostate cancer with polymorphisms in four genes: AKR1C3, HSD17B1, NQO1, and GSTT1.
|
17507624 |
2007 |
Malignant neoplasm of prostate
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the germline variants in HSD17B1 characterized by these htSNPs do not substantially influence the risk of prostate cancer in U.S. and European whites.
|
16311626 |
2005 |
Endometrioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Steroidogenic enzyme and key decidualization marker dysregulation in endometrial stromal cells from women with versus without endometriosis.
|
18815356 |
2009 |
Spontaneous abortion
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Abortion, Tubal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Early Pregnancy Loss
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Miscarriage
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer.
|
17507624 |
2007 |