|
Mouth Diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Characterization of arecoline-induced effects on cytotoxicity in normal human gingival fibroblasts by global gene expression profiling.
|
17682004 |
2007 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
More importantly, KNK437 significantly suppressed the growth of DNAJA1 expressing tumor in vivo.
|
31477839 |
2020 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Our results show that farnesylated DNAJA1 is a crucial chaperone in maintaining mutant p53 stabilization and targeting farnesylated DNAJA1 by atorvastatin will be critical for inhibiting p53 mutant cancer.
|
31397499 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Our results show that farnesylated DNAJA1 is a crucial chaperone in maintaining mutant p53 stabilization and targeting farnesylated DNAJA1 by atorvastatin will be critical for inhibiting p53 mutant cancer.
|
31397499 |
2019 |
|
Sore to touch
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
The present results suggest that meat tenderness in Nellore cattle does not directly depend on the expression of the CAPN1 and CAPN2 genes, but is associated with the expression of other genes such as CAST2, HSP90AA1, DNAJA1 and HSPB1.
|
29331838 |
2018 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Our study reveals that DNAJA1 controls the fate of misfolded mutp53, provides insights into potential strategies to deplete mutp53 through the mevalonate pathway-DNAJA1 axis, and highlights the significance of p53 status in impacting statins' efficacy on cancer therapy.
|
27775703 |
2016 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Our study reveals that DNAJA1 controls the fate of misfolded mutp53, provides insights into potential strategies to deplete mutp53 through the mevalonate pathway-DNAJA1 axis, and highlights the significance of p53 status in impacting statins' efficacy on cancer therapy.
|
27775703 |
2016 |
|
Sore to touch
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Nine were down-regulated in the same meats, but only DNAJA1 [the results relating to DNAJA1 and its relationship with tenderness have been patented (Genomic marker for meat tenderness; Patent EP06300943.5, September 12, 2006)], which encodes a heat shock protein, showed a strong negative correlation with tenderness that alone explained 63% of its variability.
|
17547415 |
2007 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We screened the mRNA expression of tumor-associated antigens (TAAs) from the literature (fibromodulin, survivin, OFA-iLRP, BAGE, G250, MAGE1, PRAME, proteinase, syntaxin, hTERT, WT-1) and TAAs defined previously by serological analysis of cDNA expression libraries from leukemic cells (PINCH, HSJ2, MAZ, MPP11, RHAMM/CD168, NY-Ren60).
|
16773189 |
2006 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High level of DNAJA1 predicted poor prognosis for CRC patients.
|
31477839 |
2020 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
DNAJA1 promoted CRC cell proliferation in vitro and tumor growth and metastasis in vivo.
|
31477839 |
2020 |
|
Seizures
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Truncating biallelic variant in DNAJA1, encoding the co-chaperone Hsp40, is associated with intellectual disability and seizures.
|
30972502 |
2019 |
|
Intellectual Disability
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Truncating biallelic variant in DNAJA1, encoding the co-chaperone Hsp40, is associated with intellectual disability and seizures.
|
30972502 |
2019 |
|
Spinocerebellar Ataxia Type 7
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We further identified altered expression of two disease-relevant transcripts in SCA7 patient cells: a twofold increase in levels of the HSP DNAJA1 and a twofold decrease in levels of the de-ubiquitinating enzyme, UCHL1.
|
24667781 |
2014 |
|
Japanese Encephalitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study is the first to demonstrate Hdj2 involved in JEV replication, providing insight into a potential therapeutic target and cell-based vaccine development of JEV infection.
|
21999493 |
2011 |
|
Malignant Pleural Mesothelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of the minimal common areas of frequent gains and losses identified candidate genes that may be involved in different stages of MM: OSM (22q12.2), FUS1 and PL6 (3p21.3), DNAJA1 (9p21.1) and CDH2 (18q11.2-q12.3).
|
18973227 |
2009 |
|
Muscular Dystrophy, Oculopharyngeal
|
0.010 |
Biomarker
|
disease |
LHGDN |
Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy.
|
11796717 |
2002 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease.
|
10717003 |
2000 |
|
Bulbo-Spinal Atrophy, X-Linked
|
0.010 |
Biomarker
|
disease |
BEFREE |
Previous studies suggested that HSPs might protect against inclusion formation, because overexpression of HDJ-2/HSDJ (a human HSP40 homologue) reduced ataxin-1 (SCA1) and androgen receptor (SBMA) aggregate formation in HeLa cells.
|
10717003 |
2000 |