XIAP, X-linked inhibitor of apoptosis, 331

N. diseases: 321; N. variants: 16
Disease: Childhood Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.050 Biomarker disease BEFREE Here, we discuss targeting XIAP, a strategy to restore TRAIL sensitivity in leukemia to acquire more insights into the mechanisms of TRAIL resistance. 30257312 2018
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.050 Biomarker disease BEFREE X-linked inhibitor of apoptosis protein (XIAP) promotes the progression of leukemia by preventing tumor cells undergoing apoptosis. 29434799 2018
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.050 AlteredExpression disease BEFREE Altogether these findings raise the possibility that embelin alone or in combination with inhibitors of PI3-kinase/AKT pathway may have therapeutic usage in leukemia and possibly other malignancies with up-regulated XIAP pathway. 28704451 2017
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.050 GeneticVariation disease BEFREE This study justifies further ex vivo and animal studies on the potential of the treatment of leukemia and lymphoma with a combination of BH3 mimetics and XIAP inhibitors. 21442307 2011
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.050 Biomarker disease BEFREE Because both XIAP and p53 are presently being targeted in ongoing clinical trials in leukemia, the combination strategy holds promise for expedited translation into the clinic. 19897582 2010