|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Injury derived autoimmunity: Anti-perlecan/LG3 antibodies in transplantation.
|
31029511 |
2019 |
|
Presenile dementia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
We also characterised the effects of hippocampal CA1 injection of p17 on epidermal growth factor receptor-1 (EGFR1) expression linked to our murine model of dementia. p17 strongly induced angiogenesis of HbMEC (migration, tube formation and spheroid growth). p17 concomitantly increased phosphorylation of EGFR1 as well as down-stream intermediates ERK1/2, FAK, PLC-γ and PKC-β whilst an inhibitor peptide of EGFR, blocked cell signalling and angiogenesis.
|
30390010 |
2019 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that the heart failure milieu caused a 2-fold enrichment of extracellular matrix proteins (ECM) like biglycan, versican, collagen XII, and angiogenic factors like heparan sulfate proteoglycan 2, plasminogen activator inhibitor 1 in the secretome.
|
30575044 |
2019 |
|
Chronic Lymphocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The functional relevance of BTK for lymphoid malignancies is strongly supported by the observation that resistance to therapy in CLL patients treated with BTK inhibitors such as ibrutinib is often associated with mutations in genes coding for BTK or Phospholipase-C gamma (PLCɣ).
|
30700840 |
2019 |
|
Mastocytosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Concentrations of DAG (18:1 20:4 and 18:0 20:4), two second messengers produced by PLC, were higher in mastocytosis compared to controls, whereas the concentrations of their metabolite, 2-AG, were not altered.
|
31355297 |
2019 |
|
Androgen-Insensitivity Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to determine the association between HSPG2 and AIS in the Chinese patients and to further investigate its influence on the phenotype of the patients.
|
30646882 |
2019 |
|
Thrombocytopenia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The Perceval S bioprosthesis (LivaNova PLC, London, United Kingdom) is based on the Freedom Solo aortic bioprosthesis (LivaNova PLC), which has been reported to be associated with perioperative thrombocytopenia.
|
31668534 |
2019 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
PPD also inhibited tumor volume and tumor lung metastasis in PLC/PRF/5 xenograft model.
|
31431619 |
2019 |
|
Liver Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thereafter, IPA software was used to analyze potential effects of these genes, and the predicted results suggested that the Reg-mediated JAK/STAT, NF-κB, MAPK (ERK1/2, P38 and JNK), PLC, and PI3K/AKT signaling pathways may account for the activated inflammation and cell proliferation, and the attenuated apoptosis and cell death during the occurrence of AHF and HCC.
|
30600408 |
2019 |
|
HELLP Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that an increased placental perlecan expression may be associated with hypoxic ischaemic injury of the placenta in miscarriages and in early preeclampsia with or without HELLP syndrome.
|
31259093 |
2019 |
|
Lung Diseases, Interstitial
|
0.010 |
Biomarker
|
group |
BEFREE |
To our knowledge, this is the first case of SJS/TEN-induced ILD that was successfully treated with etanercept.
|
31436331 |
2019 |
|
Adolescent idiopathic scoliosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Rare variant of HSPG2 is not involved in the development of adolescent idiopathic scoliosis: evidence from a large-scale replication study.
|
30646882 |
2019 |
|
Dementia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
We also characterised the effects of hippocampal CA1 injection of p17 on epidermal growth factor receptor-1 (EGFR1) expression linked to our murine model of dementia. p17 strongly induced angiogenesis of HbMEC (migration, tube formation and spheroid growth). p17 concomitantly increased phosphorylation of EGFR1 as well as down-stream intermediates ERK1/2, FAK, PLC-γ and PKC-β whilst an inhibitor peptide of EGFR, blocked cell signalling and angiogenesis.
|
30390010 |
2019 |
|
Pregnancy associated hypertension
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
For prostaglandin‑H2 D‑isomerase (L‑PGDS), perlecan and other 15 proteins, the contents in patients with gestational hypertension were higher than that of normal pregnancies, but lower in mild and severe preeclampsia.
|
30720087 |
2019 |
|
Overactive Bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
At low concentrations only, the effect of sildenafil on bladder contractility is dependent on NO/cGMP. cGMP intracellularly-elevated by sildenafil, may inhibit the activity of PLC and hence the cascade of EP<sub>1</sub>-receptors, thus masking the hyperactivity of bladder caused by alprostadil, which adds to the advantages of this combination.
|
31195343 |
2019 |
|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
Perlecan therefore appears to regulate pericyte recruitment through the cooperative functioning of PDGFRβ and integrin α5β1 to support BBB maintenance and repair following ischemic stroke.
|
31541017 |
2019 |
|
Hypopharyngeal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This results in increased concentration of HSPG on FaDu cell surface, and possibly creates a barrier for cellular uptake of highly charged COL/CPP.
|
30769789 |
2019 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
It is therefore reasonable to say that PLC Rice products offer high added value, as it not only facilitates adhesion to LPD but also add satisfaction and contentment to daily meals, helping to enhance the quality of life of patients with CKD.
|
31619617 |
2019 |
|
Triple Negative Breast Neoplasms
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that HSPG2 is a promising target in metastatic TNBC and HSPG2-targeted antibodies could represent a potentially novel class of targeted therapeutics for TNBC.
|
31462656 |
2019 |
|
Miscarriage
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that an increased placental perlecan expression may be associated with hypoxic ischaemic injury of the placenta in miscarriages and in early preeclampsia with or without HELLP syndrome.
|
31259093 |
2019 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that HSPG2 is a promising target in metastatic TNBC and HSPG2-targeted antibodies could represent a potentially novel class of targeted therapeutics for TNBC.
|
31462656 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PLC enzymes and the expression of the corresponding genes in liver biopsies from individuals deceased for complications of the alcoholic liver disease (ALD) at different stages compared with normal controls (deceased individuals with histologically normal livers without alcohol addiction anamnesis) were analyzed by using immunohistochemistry and molecular biology techniques.
|
30426534 |
2018 |
|
Brain Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, HSPGs play an important role in the development of specific synaptic connectivity patterns important for neural circuit function, and their dysfunction may be involved in the development of brain disorders.
|
29434536 |
2018 |
|
Contracture
|
0.010 |
Biomarker
|
disease |
BEFREE |
The role of PLC-IP3 cascade on 4-aminopyridine (4-AP) contracture in electrically-driven rat atrial and diaphragmatic strips: new evidence by neomycin and heparin.
|
30403592 |
2018 |
|
Eosinophilia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study demonstrates that allergen exposure reduces expression of Hs2st; loss of uronyl 2-O-sulfation in endothelial and leukocyte HSPG amplifies recruitment of eosinophils likely due to a compromised vascular endothelium resulting in persistent inflammation whereas loss of N-sulfation limits eosinophilia and attenuates inflammation underscoring the importance of site-specific sulfation in HSPG to their role in AAI.
|
29621420 |
2018 |