HTN1, histatin 1, 3346

N. diseases: 19; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder 		0.300 Biomarker disease CTD_human Phosphorylation level of four specific salivary phospho-peptides, namely statherin, histatin 1 (both, p < 0.0001) and acidic proline-rich proteins (both entire and truncated isoforms) (p < 0.005) was found significantly lower in autistic patients, with hypo-phosphorylation of at least one peptide observed in 18 ASD subjects (66%). 19367726 2008
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.020 Biomarker disease BEFREE Abbreviations BBB blood-brain barrier CDC25B cell division cycle 25 homolog B CYP2D6 Cytochrome P450 2D6 binding DCCM dynamic cross-correlation map DS Discovery Studio H bond hydrogen bond HIA human intestinal absorption LAR leukocyte antigen-related phosphatase MD molecular dynamics MEG-2 maternal-effect germ-cell defective 2 MM-PBSA molecular mechanics Poisson Boltzmann surface area) PCA principal component analysis PDB Protein Data Bank pNPP p-nitrophenyl phosphate PPB plasma protein binding PTP1B protein tyrosine phosphotase 1B RMSD root mean square deviation RMSF root mean square fluctuation SHP-1 src homologous phosphatase-1 SHP-2 src homologous phosphatase-2 SPC single-point charge TCPTP T cell protein tyrosine phosphatase T2DM Type 2 diabetes mellitus VDW van der Waals Communicated by Ramaswamy H. Sarma. 31490104 2019
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.020 Biomarker disease BEFREE Compared with the reference BMI group (18·5-22·9 kg/m2), they had an increased PR for HTN (1·55-1·77) and T2DM (1·54-1·93). 28112066 2017
CUI: C0013238
Disease: Dry Eye Syndromes
Dry Eye Syndromes 		0.010 Biomarker disease BEFREE H1 concentrations are lower in ADDE patients and H1 may have diagnostic potential in evaluation ADDE patients. 31311993 2019
CUI: C0314719
Disease: Dryness of eye
Dryness of eye 		0.010 Biomarker phenotype BEFREE H1 concentrations are lower in ADDE patients and H1 may have diagnostic potential in evaluation ADDE patients. 31311993 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.010 Biomarker disease BEFREE MAB + EBRT + PPB is extremely effective in patients with localized, high-risk PCa, indicating that PPB may play a synergistic role in improving PSA kinetics and independently predicts oncologic outcomes. 29890979 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.010 AlteredExpression group BEFREE Patients with hypertension were divided into 2 stages according to blood pressure (BP) levels or medication use (HTN-1: BP, 140-159/90-99 or use of 1 or 2 antihypertensive drugs; HTN-2: BP, ≥160/100 or use of ≥3 drugs). 28077386 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.010 Biomarker phenotype BEFREE In addition, Hst1 counteracted the effects of epithelial-mesenchymal transition inducers on the outgrowth of oral cancer cell spheroids, suggesting that Hst1 affects processes that are implicated in cancer progression.-Van Dijk, I. 28522595 2017
CUI: C4020703
Disease: Cystic lung lesion
Cystic lung lesion 		0.010 GeneticVariation disease BEFREE A cystic lung lesion in the context of a normal mid-second-trimester ultrasound is highly suggestive of a cystic PPB. 28884206 2017
CUI: C4551552
Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1
Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1 		0.010 AlteredExpression disease BEFREE Future studies will be performed to use these cell markers to isolate and culture lacrimal epithelial cells from heterogeneous tissues, determine the relevance of histatin-1 expression to DES, and isolate candidate precursor cells from ALG tissue. 27612554 2017
CUI: C1510472
Disease: Drug Dependence
Drug Dependence 		0.010 GeneticVariation group BEFREE A variant of the ADH1B gene (rs1229984 or rs1229984;rs750891770;s750891770" genes_norm="125;64129">Arg48His; previously referred to as Arg [*1] and His [*1]) has been reported to be associated with reduced rates of alcohol and drug dependence. 21497796 2011
CUI: C0023645
Disease: Lichen planus follicularis
Lichen planus follicularis 		0.010 AlteredExpression disease BEFREE We explored the degree of similarity between LPP and PPB gene expression patterns and the potential for common and unique gene pathway and gene activity in LPP and PPB using microarrays. 19932600 2010
CUI: C1266144
Disease: Pleuropulmonary blastoma
Pleuropulmonary blastoma 		0.010 AlteredExpression disease BEFREE We explored the degree of similarity between LPP and PPB gene expression patterns and the potential for common and unique gene pathway and gene activity in LPP and PPB using microarrays. 19932600 2010
CUI: C0027654
Disease: Embryonal Neoplasm
Embryonal Neoplasm 		0.010 Biomarker disease BEFREE The PPB genetic profile remains to be established and compared to others embryonal neoplasia. 16396677 2006
CUI: C0002452
Disease: Amelogenesis Imperfecta
Amelogenesis Imperfecta 		0.010 GeneticVariation disease BEFREE An identified human enamelin BAC genomic clone was shown to contain markers D4S2604 and D4S2670, as well as the first exon of the human ameloblastin gene, placing enamelin in the critical amelogenesis imperfecta locus between markers HIS1 and D4S2604 at 4q21. 11037750 2000
CUI: C0023418
Disease: leukemia
leukemia 		0.010 Biomarker disease BEFREE The precise function of the His-1 gene is unknown, but its transcriptional activation in a series of mouse leukemias has implicated the His-1 RNA in leukemogenesis when it is abnormally expressed. 9094986 1997
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 AlteredExpression phenotype BEFREE These data indicate that the His-1 gene expression is highly restricted and suggest that inappropriate activation of this gene may contribute to carcinogenesis. 9094986 1997
CUI: C0598766
Disease: Leukemogenesis
Leukemogenesis 		0.010 AlteredExpression disease BEFREE The precise function of the His-1 gene is unknown, but its transcriptional activation in a series of mouse leukemias has implicated the His-1 RNA in leukemogenesis when it is abnormally expressed. 9094986 1997
CUI: C0023470
Disease: Myeloid Leukemia
Myeloid Leukemia 		0.010 Biomarker disease BEFREE His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia. 1682866 1991
CUI: C0023488
Disease: Leukemia, Radiation-Induced
Leukemia, Radiation-Induced 		0.010 GeneticVariation disease BEFREE The His-1 locus maps to mouse chromosome 2 distinct from any known oncogene or common site of integration but near the proximal breakpoint for a deletion that is observed in over 90% of radiation-induced leukemias. 1682866 1991