Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
<b>Conclusions:</b> The interactions between 5-HT1A and VEGF gene polymorphisms may play a key role in the development of MDD in the Northern Chinese Han population.
|
31057436 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
|
19590397 |
2009 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder.
|
20453658 |
2010 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional promoter polymorphism in the serotonin receptor 1A (5-HT1A) gene has been found to be associated with major depression as well as anxiety- and depression-related personality traits.
|
14984628 |
2004 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
A Novel Alternative Splicing Mechanism That Enhances Human 5-HT1A Receptor RNA Stability Is Altered in Major Depression.
|
30093565 |
2018 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A preliminary association study between serotonin transporter (5-HTTLPR), receptor polymorphisms (5-HTR1A, 5-HTR2A) and depression symptom-clusters in a north Indian population suffering from Major Depressive Disorder (MDD).
|
31228794 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
A total of 26 outpatients with treatment-resistant MDD and 27 matched healthy controls underwent magnetic resonance imaging and genotyping for six SNPs in monoaminergic genes [serotonin transporter (SLC6A4), norepinephrine transporter (SLC6A2), serotonin 1A and 2A receptors (HTR1A and HTR2A), catechol-O-methyltransferase (COMT), and brain-derived neurotrophic factor (BDNF)].
|
25990886 |
2015 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association analysis for the C-1019G promoter variant of the 5-HT1A receptor gene with auditory evoked potentials in major depression.
|
15539859 |
2004 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Concerning neuroreceptor PET imaging, decreased 5-HT(1A) binding potential in the raphe, medial temporal lobe, and medial prefrontal cortex (mPFC) has been strongly associated with MDD, and may be impacted by a functional single nucleotide polymorphism in the promoter region of the 5-HT(1A) gene (HTR1A: -1019 C/G; rs6295).
|
19358877 |
2009 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Despite the fact that the contribution of the "genome" remains elusive when it comes to major depression, intriguing evidence has recently emerged pointing to sexually dimorphic influences of certain polymorphisms in genes related to the pathophysiology of major depression and antidepressant response, such as the serotonin transporter (5-HTT), serotonin 1A (5HT1A) receptor, monoamine oxidase A (MAO-A) and others.
|
20459391 |
2010 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Effect of 5-HT1A gene polymorphisms on antidepressant response in major depressive disorder.
|
18484082 |
2009 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Future studies should evaluate the role of genetic and environmental factors in producing elevated 5-HT(1A) BP(F) and MDD, and should examine whether 5-HT(1A) BP(F) is a vulnerability factor to MDEs that could have a role in screening high-risk populations for MDD.
|
19458612 |
2009 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Genotyped and determined 5-HT(1A) binding potential (BP) by positron emission tomography (PET) using [carbonyl-C-11]-WAY-100635 in 28 medication-free MDD subjects during a current major depressive episode and 43 controls.
|
16154547 |
2006 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genotyped and determined 5-HT(1A) binding potential (BP) by positron emission tomography (PET) using [carbonyl-C-11]-WAY-100635 in 28 medication-free MDD subjects during a current major depressive episode and 43 controls.
|
16154547 |
2006 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In MDD, however, the effect of the val66met polymorphism is not detectable, possibly due to a ceiling effect of over-expression of 5-HT(1A) receptors in mood disorders.
|
24607934 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In MDD, however, the effect of the val66met polymorphism is not detectable, possibly due to a ceiling effect of over-expression of 5-HT(1A) receptors in mood disorders.
|
24607934 |
2014 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In our study, the HTR1A C(-1019)G polymorphism was found to be associated to the frequent clinical presentation of comorbid MD and GAD, suggesting a common genetic background for mixed depression and anxiety states.
|
21512427 |
2011 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In self-identified white patients with major depressive disorder (N=126) treated with open-label duloxetine (60-120 mg/d), a significant association of (P=0.020) of a composite risk score (based on SLC6A2 rs5569 [G1287A] AA, HTR1A rs6295 [C(-1019)G] GG, and COMT rs174697 AA/AG) with 17-item Hamilton Depression Rating Scale total score change from baseline to 12 weeks was observed.
|
22727709 |
2012 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Interaction of 5-HTT and HTR1A gene polymorphisms in treatment responses to mirtazapine in patients with major depressive disorder.
|
24911443 |
2014 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interaction of 5-HTT and HTR1A gene polymorphisms in treatment responses to mirtazapine in patients with major depressive disorder.
|
24911443 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lhpp or a product of a collinear brain-specific transcript, therefore, may interact with Htr1a in the pathogenesis of major depression.
|
18268499 |
2009 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Little is known about the serotonin-1A receptor (5-HT1A) in bipolar depression despite altered 5-HT1A binding in major depressive disorder.
|
19278673 |
2009 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Multiple lines of research have implicated the serotonin 1A (5-HT1A) receptor in major depressive disorder (MDD).
|
25578798 |
2015 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Over-expression of the 5-HT1A autoreceptor has been implicated in reducing serotonergic neurotransmission, and is associated with major depression and suicide.
|
21619616 |
2011 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of the serotonin transporter (5-HTTLPR) and 5-HT1a receptor are associated with increased amygdala activation investigated with functional MRI in patients with MD.
|
18644006 |
2008 |