|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
Buspirone is a serotonin (5-HT)1A receptor partial agonist used in the treatment of anxiety disorders and may, therefore, have a treatment role for patients with AS.
|
30681431 |
2019 |
|
Anxiety Disorders
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in genes coding for the serotonin receptor subtype 1A (HTR1A), the serotonin transporter (SLC6A4), and the serotonin degrading enzyme monoamine oxidase A (MAOA) are associated with anxiety, impulsivity, and neurotic personality in humans.
|
31045220 |
2019 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
These results suggest that markedly reduced 5-HT1A autoreceptors may provide a marker for aberrant response to SSRI treatment.<b>SIGNIFICANCE STATEMENT</b> Serotonin-selective reuptake inhibitors (SSRIs) are effective in treating anxiety and depression in humans and mouse models.
|
30552180 |
2019 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
The selective serotonin reuptake inhibitor fluoxetine and the 5-HT1A receptor agonist buspirone are used to treat depression and anxiety.
|
31244623 |
2019 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
Previous in vitro studies have shown that it's crude ethanolic extracts and some alkaloidal phytoconstituents possesses high affinity for the serotonin transporter protein (SERT) and serotonin receptor 1a (5HT<sub>1a</sub>) which are both implicated in the pathogenesis and treatment of anxiety disorders.
|
29223391 |
2018 |
|
Anxiety Disorders
|
0.300 |
GeneticVariation
|
group |
BEFREE |
We thus conducted a structural equation model (SEM) to examine whether the HTR1A rs6295 variant can affect anxiety by altering parasympathetic nervous activity.
|
29363117 |
2018 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
Tandospirone, an azapirone derivative with strong and selective agonist effect on 5-HT1A receptor, has been used for the treatment of anxiety disorders especially generalized anxiety disorder for decades.
|
29254282 |
2017 |
|
Anxiety Disorders
|
0.300 |
AlteredExpression
|
group |
BEFREE |
electronic database was used as source of the studies selected selected based on the studies found by crossing the following keywords: cannabidiol and panic disorder; canabidiol and anxiety, cannabidiol and 5-HT1A receptor).
|
27157263 |
2017 |
|
Anxiety Disorders
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Targeting specific transcription factors, such as Freud-1, to restore transcriptional balance may augment response to antidepressant treatment.<b>SIGNIFICANCE STATEMENT</b> Altered regulation of the 5-HT1A autoreceptor has been implicated in human anxiety, major depression, suicide, and resistance to antidepressants.
|
29101244 |
2017 |
|
Anxiety Disorders
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The aim was to further characterize the impact of cue acquisition and trait anxiety, and of a single nucleotide polymorphism in the serotonin 1A receptor gene (5-HTR1A, rs6295), on cued fear and contextual anxiety before and after fear contingencies were explicitly introduced.
|
25448266 |
2015 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
In this review, we examine the function of 5-HT(1A) receptor subpopulations and re-interpret our understanding of their role in mental illness in light of new data, separating both spatial (autoreceptor versus heteroreceptor) and the temporal (developmental versus adult) roles of the endogenous 5-HT(1A) receptors, emphasizing their distinct actions in mediating anxiety and depression-like behaviors.
|
24337875 |
2014 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
This work indicates that the effects of 5-HT1A autoreceptors on anxiety and social behaviors are developmentally mediated and suggests that natural variations in the expression of 5-HT1A may act during development to influence individual anxiety levels and contribute to susceptibility to anxiety disorders.
|
23907404 |
2014 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
Our results, therefore, translate evidence from animal studies to humans and suggest a central role for HTR1A in differentiating subgroups of patients with anxiety disorders.
|
25514753 |
2014 |
|
Anxiety Disorders
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Transcriptional dys-regulation in anxiety and major depression: 5-HT1A gene promoter architecture as a therapeutic opportunity.
|
24180393 |
2014 |
|
Anxiety Disorders
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Targeted therapeutics to inhibit 5-HT(1A) autoreceptor expression and induce 5-HT(1A) heteroreceptor expression may ameliorate treatment of anxiety and major depression.
|
22826341 |
2012 |
|
Anxiety Disorders
|
0.300 |
GeneticVariation
|
group |
BEFREE |
C allele of 5-HT1A C-1019G polymorphism might be an independent risk factor for anxiety disorders in temporal lobe epilepsy.
|
22222329 |
2012 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
We investigated the possible association between depression and anxiety scores and SNPs within the HTR1A and HTR1B genes in a population sample (n=1387).
|
20638825 |
2011 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
MGD |
Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety.
|
20152131 |
2010 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
The 5-HT(1A) receptor is a metabotropic G protein-coupled receptor linked to the G(i/o) signaling pathway and has been specifically implicated in the pathogenesis of depression and anxiety.
|
20643652 |
2010 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
Our findings further implicate relatively increased serotonin signaling, associated with a genetic variation that mediates increased 5-HT(1A) autoreceptors, in driving amygdala reactivity and trait anxiety.
|
19124686 |
2009 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
This overview of preclinical and clinical data provides strong evidence for the key role of the 5-HT1A receptor in the serotonergic dysregulation of anxiety disorders.
|
19423077 |
2009 |
|
Anxiety Disorders
|
0.300 |
AlteredExpression
|
group |
BEFREE |
Altered expression of serotonin-1A (5-HT1A) receptors, both presynaptic in the raphe nuclei and post-synaptic in limbic and cortical target areas, has been implicated in mood disorders such as major depression and anxiety.
|
19423080 |
2009 |
|
Anxiety Disorders
|
0.300 |
AlteredExpression
|
group |
BEFREE |
As such, the level of expression of 5-HT1A receptors is implicated in the development of anxiety and depression phenotypes.
|
18639564 |
2008 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
In this study, we examined the serotonin 1A receptor gene, HTR1A, for its association with shared genetic risk across a range of anxiety and depression-related phenotypes.
|
18163385 |
2008 |
|
Anxiety Disorders
|
0.300 |
Biomarker
|
group |
BEFREE |
There is a growing amount of evidence showing the importance of 5-HT1A in different psychiatric disorders, from mood to anxiety disorders, moving through suicidal behaviour and psychotic disorders.
|
18047755 |
2008 |