|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Thus, the results do not support an association of the G861C polymorphism in the 5-HT1D(beta) autoreceptor gene with schizophrenia in the studied sample.
|
16059583 |
2005 |
|
Schizophrenia
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
New polymorphism for the human serotonin 1D receptor variant (5-HT1D beta) not linked to schizophrenia in five Canadian pedigrees.
|
8104876 |
1993 |
|
Depressive disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Influence and interaction of genetic polymorphisms in the serotonin system and life stress on antidepressant drug response.
|
21937687 |
2012 |
|
Depressive disorder
|
0.310 |
Biomarker
|
disease |
BEFREE |
Further studies should be carried out on the 5-HT1D binding site as it might represent a new tool in the understanding of the depressive illness.
|
8018797 |
1994 |
|
Depressive disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
Further studies should be carried out on the 5-HT1D binding site as it might represent a new tool in the understanding of the depressive illness.
|
8018797 |
1994 |
|
Autistic Disorder
|
0.300 |
Biomarker
|
disease |
CTD_human |
HTR1B and HTR2C in autism spectrum disorders in Brazilian families.
|
19038234 |
2009 |
|
Obsessive-Compulsive Disorder
|
0.300 |
Biomarker
|
disease |
CTD_human |
Single photon emission computed tomography of the brain with Tc-99m HMPAO during sumatriptan challenge in obsessive-compulsive disorder: investigating the functional role of the serotonin auto-receptor.
|
10621951 |
1999 |
|
Hypotension
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Interactions of GR127935, a 5-HT(1B/D) receptor ligand, with functional 5-HT receptors.
|
9109356 |
1997 |
|
Anorexia Nervosa
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of the common variance in candidate genes, stathmin (STMN1), serotonin receptor 1D (HTR1D), tryptophan hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF), with AN and EDs characterized by regular SV.
|
20946355 |
2011 |
|
Anorexia Nervosa
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We confirmed that common single-nucleotide polymorphisms (SNPs) within OPRD1 (rs533123, P=0.0015) confer risk for AN, and obtained suggestive evidence that common SNPs near HTR1D (rs7532266, P=0.04) confer risk for restricting-type AN specifically.
|
21079607 |
2011 |
|
Anorexia Nervosa
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Further evidence of association of OPRD1 & HTR1D polymorphisms with susceptibility to anorexia nervosa.
|
16806108 |
2007 |
|
Anorexia Nervosa
|
0.040 |
Biomarker
|
disease |
LHGDN |
Candidate genes for anorexia nervosa in the 1p33-36 linkage region: serotonin 1D and delta opioid receptor loci exhibit significant association to anorexia nervosa.
|
12740597 |
2003 |
|
Anorexia Nervosa
|
0.040 |
Biomarker
|
disease |
BEFREE |
The combined statistical genetic evidence suggests that HTR1D and OPRD1 or linked genes may be involved in the etiology of AN.
|
12740597 |
2003 |
|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
According to the degrees of the network nodes, 5-hydroxytryptamine receptor 1D (HTR1D), TIMP metallopeptidase inhibitor 1 (TIMP1), serpin family E member 1 (SERPINE1), matrix metallopeptidase 3 (MMP3) and cannabinoid receptor 2 (CNR2) were key nodes, and the expression levels of these genes were analyzed in clinical samples of CRC.
|
31452735 |
2019 |
|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In this study, the effect of ZJW extracts on 5-HTR1D expression and Wnt/β-catenin signaling pathway were investigated and contrasted with GR127935 (GR), a known 5-HTR1D antagonist, using the CRC cell line SW403.
|
29183322 |
2017 |
|
Migraine Disorders
|
0.030 |
Biomarker
|
group |
BEFREE |
Indeed, the development of sumatriptan and second generation triptans in the 1990's led to discover that these drugs produce selective cranial extracerebral vasoconstriction (via 5-HT1B receptors) and inhibition of the trigeminovascular system responses implicated in migraine (via 5-HT1D/5-HT1F receptors).
|
27465216 |
2017 |
|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Together, our findings reveal an essential role of the physiologic level of 5-HT(1D)R in pulmonary metastasis of colorectal cancer.
|
26214021 |
2015 |
|
Migraine Disorders
|
0.030 |
Biomarker
|
group |
BEFREE |
Inasmuch as one recent report found that mRNA encoding only the 5-HT1D beta receptor subtype was expressed by vascular smooth muscle of the central nervous system, the present findings suggest the importance of developing selective 5-HT1D alpha receptor agonists as a strategy to reduce the risk of myocardial infarction and possibly stroke that complicates the acute treatment of migraine headache.
|
8170966 |
1994 |
|
Migraine Disorders
|
0.030 |
Biomarker
|
group |
BEFREE |
This study points to the 5-HT1D beta receptor subtype as the putative cerebrovascular target for migraine therapeutic agents.
|
8394988 |
1993 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, in intestinal epithelium cells, we observed that 5-HT(1D)R played an important role in cell invasion via Axin1/β-catenin/MMP-7 pathway.
|
26214021 |
2015 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells.
|
25170871 |
2014 |
|
Eating Disorders
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We investigated the association of 25 single nucleotide polymorphisms (SNPs), capturing 71-91% of the common variance in candidate genes, stathmin (STMN1), serotonin receptor 1D (HTR1D), tryptophan hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF), with AN and EDs characterized by regular SV.
|
20946355 |
2011 |
|
Eating Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
Serotonergic and opioidergic neurotransmitter system alterations have been observed in people with eating disorders; the genes for the serotonin 1D receptor (HTR1D) and the opioid delta receptor (OPRD1) are found on chr1p36.3-34.3, a region identified by our group in a linkage analysis of anorexia nervosa (AN).
|
12740597 |
2003 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Survival analyses show that elevated 5-HT1D expression level predicts poor overall survival and high recurrence probability in HCC patients.
|
30561038 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In an orthotopic colorectal cancer mouse model, we demonstrated that a 5-HT(1D)R antagonist (GR127935) effectively inhibited tumor metastasis through targeting Axin1.
|
26214021 |
2015 |