Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Interaction of TPH2 and 5-HT2A Polymorphisms on Major Depressive Disorder Susceptibility in a Chinese Han Population: A Case-Control Study.
|
31019472 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (BDNF, rs6265), the serotonin transporter (SLC6A4, rs25531), the tryptophan hydroxylase 1 (TPH1, rs1800532), the 5-hydroxytryptamine receptor 2A (HTR2A, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (COMT, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression.
|
31721892 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A preliminary association study between serotonin transporter (5-HTTLPR), receptor polymorphisms (5-HTR1A, 5-HTR2A) and depression symptom-clusters in a north Indian population suffering from Major Depressive Disorder (MDD).
|
31228794 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Insomnia symptom of MDD was not resolved in patients with the A/A genotype of HTR2A-rs6311 when treated with SSRI.
|
31111219 |
2019 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to determine the relationship between the polymorphisms of -1438A/G and 102T/C in the 5-HT2A receptor (HTR2A) gene and nausea/vomiting as a side effect induced by sertraline (SERT) or citalopram (CIT) in patients with major depressive disorder.
|
30221791 |
2018 |
Major Depressive Disorder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Relative 5-HTR2A mRNA expression was significantly higher in PBMCs of all MDD patients when compared with healthy controls (Z = -3.875, p < 0.05).
|
28125323 |
2017 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Pharmacological studies have yielded valuable insights into the role of the serotonin 2A (5-HT2A) receptor in major depressive disorder (MDD) and antidepressant drugs (ADs) response.
|
26764241 |
2016 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to explore whether the variants in the 5-HT1A and 5-HT2A gene are susceptible to SZ or MDD in the Chinese Han population.
|
27756686 |
2016 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
A total of 26 outpatients with treatment-resistant MDD and 27 matched healthy controls underwent magnetic resonance imaging and genotyping for six SNPs in monoaminergic genes [serotonin transporter (SLC6A4), norepinephrine transporter (SLC6A2), serotonin 1A and 2A receptors (HTR1A and HTR2A), catechol-O-methyltransferase (COMT), and brain-derived neurotrophic factor (BDNF)].
|
25990886 |
2015 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia.
|
24962835 |
2014 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis.
|
25270656 |
2014 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggested that the 5-HTR2A rs6313 T>C polymorphism was significantly correlated with a higher response rate to antidepressants in MDD patients (allele model: OR=1.33, 95% CI=1.05-1.68, P=0.020; dominant model: OR=1.62, 95% CI=1.21-2.18, P=0.001; homozygous model: OR=1.85, 95% CI=1.18-2.90, P=0.008).
|
25108775 |
2014 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Accordingly, two single nucleotide polymorphisms of the HTR2A gene (rs6314 ie His452Tyr and rs6313 ie rs6313" genes_norm="3356">102C/T), which specific allelic variants may decrease 5-HT2AR-mediated transmission (as in Htr2a(-/-)mice), were studied in a sample of 485 Caucasian patients with MDD.
|
24801750 |
2014 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Association of the T102C polymorphism in the HTR2A gene with major depressive disorder, bipolar disorder, and schizophrenia.
|
24962835 |
2014 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Our findings suggested that the 5-HTR2A rs6313 T>C polymorphism was significantly correlated with a higher response rate to antidepressants in MDD patients (allele model: OR=1.33, 95% CI=1.05-1.68, P=0.020; dominant model: OR=1.62, 95% CI=1.21-2.18, P=0.001; homozygous model: OR=1.85, 95% CI=1.18-2.90, P=0.008).
|
25108775 |
2014 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Accordingly, two single nucleotide polymorphisms of the HTR2A gene (rs6314 ie His452Tyr and rs6313 ie 102C/T), which specific allelic variants may decrease 5-HT2AR-mediated transmission (as in Htr2a(-/-)mice), were studied in a sample of 485 Caucasian patients with MDD.
|
24801750 |
2014 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of HTR2A T102C and A-1438G polymorphisms with susceptibility to major depressive disorder: a meta-analysis.
|
25270656 |
2014 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found that the association of the HTR2A -1438A/G polymorphism with SZ depends on the ethnic origin of the study population, and this genetic variant does not modify the susceptibility to BD or MDD.
|
23404241 |
2013 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Preclinical and imaging/post-mortem studies in humans provide strong support for the involvement of HTR1A and HTR2A genes in MD.
|
23547754 |
2013 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Several studies in major depression have implicated a role of the serotonin receptor gene (HTR2A) in treatment response to antidepressants.
|
22006095 |
2013 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No significant association between the 5-HTR2A gene SNP rs6311 and the risk of MDD was observed by four genetic models in the current meta-analysis (P = 0·12 for A versus G; P = 0·11 for AA versus GG; P = 0·06 for AA+AG versus GG; P = 0·24 for AG+GG versus AA).
|
23317793 |
2013 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To explore the possible relationship between six single nucleotide polymorphisms (SNPs) (rs6311 and rs6305 of 5-HT2A, rs5443 of Gβ3, rs2230739 of ACDY9, rs1549870 of PDE1A and rs255163 of CREB1, which are all related with 5-HT2A the signal transduction pathway) and the response efficacy to selective serotonin reuptake inhibitor (SSRI) treatments in major depressive disorder (MDD) Chinese.
|
22480177 |
2012 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this prospective study was to examine whether the 5-HT2A receptor -1438 G/A polymorphism has functional consequences on sexual well-being in young adult men presenting with their first episode of major depressive disorder (MDD) after serotonergic antidepressant treatment.
|
22612784 |
2012 |
Major Depressive Disorder
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The aim of this prospective study was to examine whether the 5-HT2A receptor -1438 G/A polymorphism has functional consequences on sexual well-being in young adult men presenting with their first episode of major depressive disorder (MDD) after serotonergic antidepressant treatment.
|
22612784 |
2012 |
Major Depressive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interaction between two HTR2A polymorphisms and gender is associated with treatment response in MDD.
|
21741447 |
2011 |