HTR4, 5-hydroxytryptamine receptor 4, 3360

N. diseases: 80; N. variants: 26
Disease: Atrial Fibrillation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.320 Biomarker disease BEFREE Quantitative mRNA analysis of serotonin 5-HT4 receptor isoforms, calcium handling proteins and ion channels in human atrial fibrillation. 17418812 2007
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.320 AlteredExpression disease BEFREE This supports the hypothesis that the observed alterations in mRNA transcription in AF patients may lead to a decrease in the availability of functional L-type Ca2+-channels and 5-HT4-receptors and/or reduce L-type Ca2+-current amplitude and density, thus, promoting and stabilizing the arrhythmia. 11215536 2001
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation 		0.320 Therapeutic disease CTD_human Do human atrial 5-HT4 receptors mediate arrhythmias? 7886817 1994