HYAL1, hyaluronidase 1, 3373

N. diseases: 58; N. variants: 5
Disease: Neoplasm Metastasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE The suppressive role of HYAL1 and HYAL2 in the metastasis of colorectal cancer. 30972813 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE The hyaluronidase Hyal1 is clinically and functionally implicated in prostate cancer progression and metastasis. 29753676 2019
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 AlteredExpression phenotype BEFREE Urine and tissue HAase/HYAL-1 levels are sensitive markers for high-grade bladder cancer (BCa) and its metastasis. 27419371 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 AlteredExpression phenotype BEFREE In clinical specimens and TCGA data sets, HA synthases and hyaluronidase-1 levels significantly predicted metastasis and poor survival. 28972965 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 AlteredExpression phenotype BEFREE In univariate and multivariate analyses, tumor stage (P = .003), lymph node invasion (P = .033), HYAL-1 (P = .019), and HAS1 (P = .027) transcript levels, and HYAL-1 staining (P = .021) were independently associated with metastasis. 20960509 2011
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE Although HYAL-1 is a critical determinant of tumor progression and a marker for cancer diagnosis and metastasis prediction, it has not been evaluated as a target for cancer therapy. 21555367 2011
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.070 Biomarker phenotype BEFREE We previously used prostate tumor cells overexpressing the HA synthesizing enzyme HAS3 or the clinically relevant hyaluronidase Hyal1 to show that excess HA production suppresses tumor growth, while HA turnover accelerates spontaneous metastasis from the prostate. 21315068 2011