|
insulinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Amylin was later characterized as an amyloidogenic peptide, confined from a beta cell tumor and called islet amyloid polypeptide (IAPP), and after that, amylin.
|
31004596 |
2019 |
|
insulinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytotoxic human amylin additionally stimulated pro-oxidative activity and expressions of plasma membrane bound NADPH oxidase (NOX) and its regulatory subunits. siRNA mediated NOX1 knockdown and selective NOX inhibitors, ML171 and apocynin, significantly reduced hA-induced mitochondrial stress in insulinoma beta-cells.
|
29627323 |
2018 |
|
insulinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since pitrilysin is a mitochondrial protein, we used immunofluorescence staining of pancreases from human IAPP transgenic mice and Western blot analysis of IAPP in isolated mitochondria from insulinoma cells to provide evidence for a putative intramitochondrial pool of IAPP.
|
26191799 |
2015 |
|
insulinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide.
|
14613923 |
2004 |
|
insulinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated IAPP expression in relation to insulin expression and to amyloid formation in eleven insulinomas.
|
10037255 |
1999 |
|
insulinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Several endogenous genes expressed in normal beta-cells, including rat insulin, amylin, sulfonylurea receptor, and glucokinase, are stably expressed in the insulinoma lines during these in vivo studies.
|
9166666 |
1997 |
|
insulinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that in normal human pancreas the IAPP gene transcripts differ in size from those reported for human insulinoma.
|
8050128 |
1994 |
|
insulinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results demonstrate for the first time that amylin immunoreactivity is not restricted to insulinomas and can also occur rarely in endocrine tumors of the intestine.
|
8317551 |
1993 |
|
insulinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Islet amyloid polypeptide (IAPP or amylin) was first identified as the major peptide constituent of amyloid deposited in the islets of Langerhans in patients with type-2 diabetes mellitus or in insulinomas.
|
8323756 |
1993 |
|
insulinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
No constant relationship between islet amyloid polypeptide (IAPP) and insulin expression in insulinomas.
|
1362976 |
1992 |
|
insulinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IAPP mRNA was confined to the beta-cell phenotype when analyzing the phenotypically stable in vivo tumor lines, MSL-G2-IN (insulinoma) and MSL-G-AN (glucagonoma), and the transgenic mouse islet cell lines, beta-Tc and alpha-Tc.
|
1850107 |
1991 |
|
insulinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show that dog IAPP contains the same putative amyloidogenic sequence (GAILS) at residues 24-28 as human and cat IAPP, and that although dogs do not develop islet amyloid they do develop IAPP-derived amyloid in association with neoplastic beta cells (i.e., insulinomas).
|
2192709 |
1990 |
|
insulinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We now report the nucleotide sequences of a human insulinoma cDNA encoding a complete IAPP precursor, and of the corresponding parts of the IAPP gene.Two exons, which are approx.
|
2651160 |
1989 |
|
insulinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have identified three cDNA clones encoding islet amyloid polypeptide (IAPP) or diabetes-associated peptide (DAP) by oligonucleotide screening of a lambda gt10 human insulinoma cDNA library.
|
3053705 |
1988 |