Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Moreover, the apoptosis‑suppressor gene baculoviral IAP repeat containing 5 BIRC5) was significantly repressed (by more than 90%) in both cell lines, as well as death‑associated protein kinase 1 (DAPK1) in MM‑231 cells and tumor protein 73 (TP73) in MM‑468 cells.
|
31173249 |
2019 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The primary tumor and detectable metastases killed the animals 29-30 days after SUM-IAP application.
|
29465464 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The combined anti-tumor activity of IAP antagonism and PD-1 blockade occurred independently of perforin-mediated tumor cell death.
|
28665401 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
RIPK3 levels varied considerably between tumors and RIPK3 was not required for IAP antagonism to sensitize osteosarcoma cells to TNFα.
|
27129149 |
2016 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Pramlintide, a synthetic analogue of amylin that is currently used to treat type 1 and type 2 diabetes, caused rapid tumour regression in p53-deficient thymic lymphomas, representing a novel strategy to target p53-deficient cancers.
|
25409149 |
2015 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This review will provide a brief introduction to recent developments of the application IAP-siRNA in tumor studies, with the aim of inspiring future treatment of HCC.
|
24175757 |
2013 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, the expression of the inhibitor-of-apoptosis (IAP) protein survivin was evaluated in pretreatment biopsies and corresponding posttreatment resection specimens, and was correlated to histo-pathological tumor characteristics and clinical follow-up.
|
21118954 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We pay particular attention to pancreatic adenocarcinoma, an aggressive tumor that has a 5-year survival rate of 3-5%, and is the fourth leading cause of cancer mortality in the US. and IAP.
|
20299817 |
2010 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Survivin is a member of the inhibitor of apoptosis (IAP) protein family that is expressed in the majority of human tumors including prostate cancer, but is barely detectable in terminally differentiated normal cells.
|
20698994 |
2010 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IAP proteins are expressed in the majority of human malignancies at elevated levels and play an active role in promoting tumor maintenance through the inhibition of cellular death and participation in signaling pathways associated with malignancies.
|
18336193 |
2008 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings demonstrate that Doxorubicin and Cisplatin do not sensitize U2OS osteosarcoma cells to TRAIL by surface receptor modulation but rather by the removal of the intracellular signalling inhibition generated by X-IAP, suggesting a foreseeable relevant advantage to the therapy of these tumors by the combined regimen of genotoxin-based chemotherapy and TRAIL.
|
16327988 |
2006 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results indicate that IAP-dependent suppression of apoptosome predominantly occurs in IAP-overexpressing tumor, and the IAP-targeting Smac peptide is an effective molecule to increase tumor cell death induced by chemotherapy in vitro and in vivo.
|
12591734 |
2003 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IAPP and insulin mRNA and peptide content varied widely between the tumour specimens, and there was considerable intratumour heterogeneity of peptide content.
|
10037255 |
1999 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Despite the identification of several new apoptosis inhibitors related to bcl-2 or to the baculovirus IAP gene, it is not clear whether apoptosis inhibition plays a general role in neoplasia.
|
9256286 |
1997 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have now begun to investigate the molecular basis of radiation-induced neoplastic transformation in this system by studying the potential genetic linkage between p75/IAP expression, tumorigenicity and damage to a putative tumor suppressor locus on fibroblast chromosome 11.
|
7597142 |
1995 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In samples from the patients with both pancreatic cancer and diabetes, immunostaining for IAPP was reduced in islets of pancreatic tissue surrounding the tumor; in situ hybridization studies suggested that transcription occurred normally in these islets.
|
8277951 |
1994 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Measurements of amylin messenger RNA expression in a few tumors revealed amylin synthesis in these tumors.
|
8317551 |
1993 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Amyloid deposits were found in one solitary tumour and in the tumour from the MEN-I patient, both staining strongly positive with anti-IAPP antibodies; cytoplasmatic IAPP was weak.
|
1362976 |
1992 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IAPP mRNA was confined to the beta-cell phenotype when analyzing the phenotypically stable in vivo tumor lines, MSL-G2-IN (insulinoma) and MSL-G-AN (glucagonoma), and the transgenic mouse islet cell lines, beta-Tc and alpha-Tc.
|
1850107 |
1991 |