|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fibrillation of human islet amyloid polypeptide and its toxicity to pancreatic β-cells under lipid environment.
|
31491457 |
2020 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
Heterotropic Modulation of Amylin Fibrillation by Small Molecules: Implications for Formulative Designs.
|
31808036 |
2020 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thioflavin T kinetics fluorescence assays, dynamic light scattering measurements, far-UV circular dichroism, and transmission electron microscopy all indicate that M1-AuNP conjugates prevent IAPP fibrillation at M1:IAPP molar ratios of as low as 1:50, while free M1 is unable to prevent fibrillation at the same substoichiometric concentrations.
|
30585717 |
2019 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
The formation of amyloid aggregates is the hallmark of many protein misfolding diseases, including Type-II diabetes mellitus, which is caused by the fibrillation of amylin protein.
|
31482893 |
2019 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
High-speed atomic force microscopy and transmission electron microscopy experiments show that PMAQA blocks the nucleation and fibrillation of amylin, whereas it induces the formation of amorphous aggregates of β-amyloid-1-40.
|
31015938 |
2019 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
We reported that both two chiral AuNPs could inhibit amylin fibrillation in a dosage-dependent manner but the inhibitory effect of <i>L</i>-NIBC-AuNPs was more effective than that of <i>D</i>-NIBC-AuNPs.
|
30862041 |
2019 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
Herein, we report that Shiitake-derived polysaccharide lentinan manipulates in vitro hIAPP fibrillation and modulates IAPP-induced cytotoxicity in a conformation-dependent manner.
|
30148596 |
2018 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
A tripyrrole, ADH-101, was the most effective antagonist of IAPP fibrillation in a physiologically relevant lipid membrane system as well as under de novo conditions.
|
29303519 |
2018 |
|
Fibrillation
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here using docking and molecular dynamic (MD) simulations studies, the work investigates key interactions between IAPP and different heparin fragments, those are likely involved in moderating IAPP fibrillation kinetics in presence of different length heparin fragments.
|
29505875 |
2018 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dual effect of PEG-PE micelle over the oligomerization and fibrillation of human islet amyloid polypeptide.
|
29535385 |
2018 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
The fibrillation of islet amyloid polypeptide (IAPP) triggered the amyloid deposition, then enhanced the loss of the pancreatic islet mass.
|
29523142 |
2018 |
|
Fibrillation
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, ESI-IMS-MS combined with analysis of fibrillation rates using thioflavin T (ThT) fluorescence, is used to track the course of aggregation of variants of islet-amyloid polypeptide (IAPP) in isolation and in pairwise mixtures.
|
28970890 |
2017 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
While monovalent Ag<sup>+</sup> up to 50 μg mL<sup>-1</sup> showed no effect on the contour length or stiffness of IAPP fibrils, multivalent Fe<sup>3+</sup> at 5 μg mL<sup>-1</sup> halted IAPP fibrillation likely through ion-peptide crosslinking.
|
28078343 |
2017 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibitory Mechanism of Epigallocatechin Gallate on Fibrillation and Aggregation of Amidated Human Islet Amyloid Polypeptide.
|
28297133 |
2017 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
IAPP fibrillation was assessed by thioflavin T assay.
|
28500395 |
2017 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
We showed that the use of this assay not only allowed the tracking of initial nucleation events, but also enabled imaging of amyloid fibrils and investigation of the effects of amyloid inhibitor/modulator toward amylin fibrillation.
|
28602190 |
2017 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
The result of proteolysis is modulation of human IAPP fibrillation and human IAPP protein degradation.
|
26840340 |
2016 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further, C4BP interacts strongly with various types of amyloid and enhances fibrillation of islet amyloid polypeptide secreted from pancreatic beta cells, which may attenuate pro-inflammatory and cytotoxic effects of this amyloid.
|
26658464 |
2016 |
|
Fibrillation
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, these experiments suggest the helical dimerization of IAPP accelerates fibril formation and that insulin impedes fibrillation by blocking the IAPP dimerization interface.
|
19475663 |
2009 |