Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human islet amyloid polypeptide (hIAPP or amylin) forms the amyloid deposits that is an important factor in the induction of type II diabetes.
|
30917341 |
2019 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
The major peptide constituent of the amyloid deposits in type 2 diabetes is islet amyloid polypeptide (IAPP).
|
26191799 |
2015 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data provide the first in vivo evidence—using a transgenic mouse model with amyloid deposits resembling those found in human islets—that IAPP-induced beta cell dysfunction in type 2 diabetes may be mediated by IL-1.
|
25491100 |
2015 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human islet amyloid polypeptide (IAPP) is the major component of pancreatic amyloid deposits in type 2 diabetes.
|
24928165 |
2014 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1β.
|
20835230 |
2010 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Amyloid deposits derived from the amylin peptide accumulate within pancreatic islet beta-cells in most cases of type-2 diabetes mellitus (T2Dm).
|
17617411 |
2007 |
Plaque, Amyloid
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Amyloid deposits were detected only in the three tumours with the highest IAPP content.
|
10037255 |
1999 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Amyloid deposits consistently showed immunoreactivity for IAPP but not for insulin.
|
8885173 |
1996 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Islet amyloid polypeptide ("amylin") is the major protein component of amyloid deposits in pancreatic islets of type 2 (non-insulin-dependent) diabetic patients.
|
7929617 |
1994 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Amyloid deposits were associated with decreased numbers of beta cells with islet amyloid polypeptide immunoreactivity despite an apparent normal frequency of insulin-containing cells.
|
8477877 |
1993 |
Plaque, Amyloid
|
0.100 |
Biomarker
|
disease |
BEFREE |
Amyloid deposits in the islets of Langerhans occur in association with type 2 diabetes mellitus (DM) in humans and cats and consist of a 37-amino-acid polypeptide known as islet amyloid polypeptide (IAPP).
|
2666169 |
1989 |